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Apo-Cyclosporine Oral 与 Pediazole

Apo-Cyclosporine Oral 与 Pediazole互相作用以及同时服用的可能性。

检测结果:

Apo-Cyclosporine Oral <> Pediazole

现实性: 21.04.2023 评论家: 医学副博士Shkutko P.M., in

在该服务的官方手册中，已注明相关研究结果统计规定的互相作用。该互相作用或对患者健康引起不良后果，或起到良好效果。具体联合用药问题，需遵从医嘱。

用户:

红霉素可能增加的血液水平和影响的环孢菌素。你可能需要一个剂量的调整，如果你已经把孢菌素和开始处理与红霉素。联系您的医生如果您的状况改变或者如果你的经验增加的副作用，例如恶心、呕吐、腹泻、腹部疼痛、头晕、疲劳、头痛、震颤、抽搐发烧，喉咙痛，不寻常的瘀伤或流血，并增加或减少排尿。重要的是要告诉你的医生关于所有其他药物的使用，包括维生素和草药。不停止使用任何药物，没有第一个说你的医生。

医界专家:

密切监测:共同给予与大环内酯类抗生素被有效的抑制剂的CYP450 3A4可能会显着增加的血液浓度的环孢霉素，其主要代谢的同工酶. 风险nephro和神经中毒相关药可能会增加。已经有许多报告的显着增加cyclosporine峰浓度(C)和系统暴露(AUC)和减少其间隙期间，伴管理的大环内酯类抗生素，特别是红霉素和克拉霉素。大环内酯，也可能大大抑制CYP450 3A4包括醋竹桃霉素、红霉素，以及克拉霉素。阿齐和dirithromycin一般都认为没有什么效果，如果有的话，在CYP450 3A4，虽然阿齐被牵连在一个单一的情况的报告。

管理：谨慎建议，如果药是使用与大环内酯类抗生素被有效的抑制剂的CYP450 3A4. Cyclosporine的血液水平和肾功能应当经常检查和剂量进行相应的调整，特别是以下启动或中止的大环内酯治疗的患者都稳定上他们的药方案。患者应建议通知他们的医生如果他们的经验可能的迹象cyclosporine的毒性，例如恶心、呕吐、腹泻、腹部疼痛、头晕、疲劳、头痛、震颤、和抽搐。替代的抗生素，不会干扰环孢霉素的新陈代谢，应考虑只要可能的。

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