简介 联系方式 药物互相作用: 390 212
根据名称进行药物检索

Cefotaxime 与 Warfarin

Cefotaxime 与 Warfarin互相作用以及同时服用的可能性。

检测结果:
Cefotaxime <> Warfarin
现实性: 12.07.2022 评论家: 医学副博士Shkutko P.M., in

在该服务的官方手册中,已注明相关研究结果统计规定的互相作用。该互相作用或对患者健康引起不良后果,或起到良好效果。具体联合用药问题,需遵从医嘱。

用户:

头孢噻可能增加的效果和华法林导致你流血更容易。 你可能需要更多的频繁监视你的印度卢比开始后头孢噻或随时停止和进行适当的调整在你的剂量,如果有必要的。 叫你的医生立即的,如果你有任何不寻常的出血瘀伤、呕吐、血液在你的尿液或凳子、头疼、头晕、或弱点在处理与这些药物。 重要的是要告诉你的医生关于所有其他药物的使用,包括维生素和草药。 不停止使用任何药物,没有第一个说你的医生。

医界专家:

监视器:菌素可能会加强抗凝血作用的维生素K拮抗剂。 可能的机制包括抑制生长的维生素K产肠道细菌、抑制生产维生素K依赖的凝血因子通过methylthiotetrazole(汤玛)侧链(例如,头孢孟多、头孢美唑头孢哌酮,孢替坦)和/或抑制血小板活动。 减少凝血酶原活动已经被报道在治疗过程中与各种菌素. 风险因素,包括肾脏或是肝脏损伤、营养不良的状态,旷日持久的抗生素治疗、慢性抗凝治疗。

管理:凝血酶原时间和印度卢比的应该监测和患者密切观察为迹象的流血。 抗凝血剂量可以调整所表明的那样。 患者应建议通知他们的医生如果他们遇到任何迹象或症状,这些症状可以表示抗凝血过多,例如不寻常的或延长的出血瘀伤、咖啡地呕吐,变化粪便或尿色、头疼、头晕、或弱点。

来源
  • Cerner Multum, Inc. "Canadian Product Information." O 0 (2015):
  • Wood T, Johnson K, Naylor S, Weinshilboum R "Cefazolin administration and 2-methyl-1,3,4-thiadiazole-5-thiol in human tissue: possible relationship to hypoprothrombinemia." Drug Metab Dispos 30 (2002): 1123-1128
  • Natelson EA, Brown CH, 3d Bradshaw MW, Alfrey CP, Jr Williams TW, Jr "Influence of cephalosporin antibiotics on blood coagulation and platelet function." Antimicrob Agents Chemother 9 (1976): 91-3
  • Chen LJ, Hsiao FY, et al "Use of Hypoprothrombinemia-Inducing Cephalosporins and the Risk of Hemorrhagic Events: A Nationwide Nested Case-Control Study." PLoS One 11 (2016): 1-11
  • "Product Information. Suprax (cefixime)." Lupin Pharmaceuticals Inc, Baltimore, MD.
  • Osborne JC "Hypoprothrombinemia and bleeding due to cefoperazone." Ann Intern Med 102 (1985): 721-2
  • Weitekamp MR, Aber RC "Prolonged bleeding times and bleeding diathesis associated with moxalactam administration." JAMA 249 (1983): 69-71
  • Angaran DM, Dias VC, Arom KV, et al "The comparative influence of prophylactic antibiotics on the prothrombin response to warfarin in the postoperative prosthetic cardiac valve patient." Ann Surg 206 (1987): 155-61
  • Khaleeli M, Giorgio AJ "Defective platelet function after cephalosporin administration." Blood 48 (1976): 791-2
  • "Product Information. Cefzil (cefprozil)." Bristol-Myers Squibb, Princeton, NJ.
  • "Product Information. Keflex (cephalexin)." Dista Products Company, Indianapolis, IN.
  • "Product Information. Maxipime (cefepime)." Bristol-Myers Squibb, Princeton, NJ.
  • "Product Information. Ceclor (cefaclor)." Lilly, Eli and Company, Indianapolis, IN.
  • "Product Information. Rocephin (ceftriaxone)." Roche Laboratories, Nutley, NJ.
  • Shearer MJ, Bechtold H, Andrassy K, Koderisch J, McCarthy PT, Trenk D, Jahnchen E, Ritz E "Mechanism of cephalosporin-induced hypoprothrombinemia: relation to cephalosporin side chain, vitamin K metabolism, and vitamin K status." J Clin Pharmacol 28 (1988): 88-95
  • "Product Information. Spectracef (cefditoren)." TAP Pharmaceuticals Inc, Deerfield, IL.
  • Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]):
  • Lipsky JJ "N-methyl-thio-tetrazole inhibition of the gamma carboxylation of glutamic acid: possible mechanism for antibiotic-associated hypoprothrombinaemia." Lancet 2 (1983): 192-3
  • Lerner PI, Lubin A "Coagulopathy with cefazolin in uremia." N Engl J Med 290 (1974): 1324
  • Bang NU, Tessler SS, Heidenreich RO, et al "Effects of moxalactam on blood coagulation and platelet function." Rev Infect Dis 4 (1982): s546-54
  • Haubenstock A, Schmidt P, Zazgornik J, et al "Hypoprothrombinaemic bleeding associated with ceftriaxone." Lancet 1 (1983): 1215-6
  • "Product Information. Ancef (cefazolin)." SmithKline Beecham, Philadelphia, PA.
  • "Product Information. Mefoxin (cefoxitin)." Merck & Co, Inc, West Point, PA.
  • "Product Information. Fortaz (ceftazidime)." Glaxo Wellcome, Research Triangle Park, NC.
  • Reddy J, Bailey RR "Vitamin K deficiency developing in patients with renal failure treated with cephalosporin antibiotics." N Z Med J 92 (1980): 378-80
  • Meisel S "Hypoprothrombinemia due to cefoperazone." Drug Intell Clin Pharm 18 (1984): 316
  • "Product Information. Claforan (cefotaxime)." Hoechst Marion-Roussel Inc, Kansas City, MO.
  • "Product Information. Cefotan (cefotetan)." Stuart Pharmaceuticals, Wilmington, DE.
  • Brown RB, Klar J, Lemeshow S, et al "Enhanced bleeding with cefoxitin or moxalactam." Arch Intern Med 146 (1986): 2159-64
  • "Product Information. Teflaro (ceftaroline)." Forest Pharmaceuticals, St. Louis, MO.
  • Agnelli G, Del Favero A, et al "Cephalosporin-Induced Hypoprothrombinemia: Is the N-Methylthiotetrazole Side Chain the Culprit?" Antimicrob Agents Chemother 29 (1986): 1108-1109
  • "Product Information. Omnicef (cefdinir)." Parke-Davis, Morris Plains, NJ.
  • Joehl RJ, Rasbach DA, Ballard JO, et al "Moxalactam: evaluation of clinical bleeding in patients with abdominal infection." Arch Surg 118 (1983): 1259-61
  • Mackie IJ, Walshe K, et al "Effects of N-methyl-thiotetrazole cephalosporin on haemostasis in patients with reduced serum vitamin K1 concentrations." J Clin Pathol 39 (1986): 1245-1249
  • Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  • "Product Information. Duricef (cefadroxil)." Bristol-Myers Squibb, Princeton, NJ.
  • Sieradzan RR, Bottner WA, Fasco MJ, Bertino JS Jr "Comparative effects of cefoxitin and cefotetan on vitamin K metabolism." Antimicrob Agents Chemother 32 (1988): 1446-9
  • "Product Information. Vantin (cefpodoxime)." Pharmacia and Upjohn, Kalamazoo, MI.
  • "Product Information. Cedax (ceftibuten)." Schering-Plough, Liberty Corner, NJ.
  • Manson JM, Zolna LE, Kang YJ, Johnson CM "Effects of cefonicid and other cephalosporin antibiotics on male sexual development in rats." Antimicrob Agents Chemother 31 (1987): 991-997
  • Cerner Multum, Inc. "Australian Product Information." O 0
  • Cristiano P "Hypoprothrombinemia associated with cefoperazone treatment." Drug Intell Clin Pharm 18 (1984): 314-6
  • "Product Information. Ceftin (cefuroxime)." Glaxo Wellcome, Research Triangle Park, NC.
  • Parker SW, Baxter J, Beam TR "Cefoperazone-induced coagulopathy." Lancet 1 (1984): 1016
Cefotaxime

非专利名称: cefotaxime

品牌: Claforan, Claforan ADD-Vantage

同义词:

Warfarin

非专利名称: warfarin

品牌: Coumadin, Jantoven

同义词:

在药物相容性与互相作用的检测过程中使用下列的信息来源:Drugs.com, Rxlist.com, Webmd.com, Medscape.com。

与食物,生活方式相互作用
与疾病相互作用