Cyclosporine 与 Ketoconazole
Cyclosporine 与 Ketoconazole互相作用以及同时服用的可能性。
在该服务的官方手册中,已注明相关研究结果统计规定的互相作用。该互相作用或对患者健康引起不良后果,或起到良好效果。具体联合用药问题,需遵从医嘱。
用户:药物可能增加的血液水平和影响的环孢菌素。 你可能需要的剂量调整或更频繁的监测通过你的医生到安全地使用这两种药物。 联系您的医生如果您的状况改变或者你的经验增加的副作用,例如恶心、呕吐、腹泻、腹部疼痛、头晕、疲劳、头痛、震颤、抽搐发烧,喉咙痛,不寻常的瘀伤或流血,并增加或减少排尿。 重要的是要告诉你的医生关于所有其他药物的使用,包括维生素和草药。 不停止使用任何药物,没有第一个说你的医生。
医界专家:调节剂量:某些唑抗真菌剂等药物和康唑被有效的抑制剂的CYP450 3A4可能显着增加,血液水平的环孢霉素,其主要代谢的同工酶. 风险nephro和神经中毒相关药可能会增加。 五到十倍的增加cyclosporine的水平已报告在共同给予与酮康唑。
管理:药用量的削减往往是必要的,在共同给予与唑抗真菌剂。 Cyclosporine的血液水平和肾功能应当经常检查和剂量进行相应的调整,特别是以下启动或停止抗真菌药治疗的患者都稳定上他们的药方案。 60%至80%的减少可能必须在伴随治疗与酮康唑。 患者应建议通知他们的医生如果他们的经验可能的迹象cyclosporine的毒性,例如恶心、呕吐、腹泻、腹部疼痛、头晕、疲劳、头痛、震颤、和抽搐。
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非专利名称: cyclosporine
品牌: Gengraf, Neoral, Sandimmune, Sandimmune
同义词: Cyclosporine (oral/injection), CycloSPORINE (Systemic)
在药物相容性与互相作用的检测过程中使用下列的信息来源:Drugs.com, Rxlist.com, Webmd.com, Medscape.com。
- Cyclosporine-Ketoconazole (Systemic)
- Cyclosporine-Ketoconazole and Hydrocortisone
- Cyclosporine-Ketoconazole Tablets
- Cyclosporine-Ketoprofen
- Cyclosporine-Ketoprofen Capsules
- Cyclosporine-Ketoprofen Extended-Release Capsules
- Ketoconazole-CycloSPORINE (Systemic)
- Ketoconazole-Cyclosporine Capsules
- Ketoconazole-Cyclosporine Capsules, Modified
- Ketoconazole-Cyclosporine Injection
- Ketoconazole-Cyclosporine Oral Solution
- Ketoconazole-Cyclosporine Oral Solution, Modified