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Diflucan (Fluconazole Tablets) 与 Nefazodone Hydrochloride

Diflucan (Fluconazole Tablets) 与 Nefazodone Hydrochloride互相作用以及同时服用的可能性。

检测结果:

Diflucan (Fluconazole Tablets) <> Nefazodone Hydrochloride

现实性: 26.01.2023 评论家: 医学副博士Shkutko P.M., in

在该服务的官方手册中，已注明相关研究结果统计规定的互相作用。该互相作用或对患者健康引起不良后果，或起到良好效果。具体联合用药问题，需遵从医嘱。

用户:

氟康唑可能增加的血液水平和影响奈法唑酮. 你可能需要的剂量调整或更频繁的监测通过你的医生到安全地使用这两种药物。联系您的医生如果您的状况改变或者你的经验，增加了侧影响。重要的是要告诉你的医生关于所有其他药物的使用，包括维生素和草药。不停止使用任何药物，没有第一个说你的医生。

医界专家:

监视器：共同给予与氟康唑可能增加等离子浓度的毒品是基底的CYP450 3A4. 该机制降低清关，由于抑制CYP450 3A4介导的新陈代谢通过氟康唑，适度的抑制剂的同工酶. 增加了30%血清卡马西平，已经观察到在共同给予与氟康唑根据产品标签。还有一些孤立的情况下报告在医学文献中描述的一个近似增加一倍的卡马西平的级别以下的外氟康唑，产生毒性。其他药物的代谢通过CYP450 3A4其血浆水平据报告，都增加氟康唑包括口服避孕药(乙炔雌二醇和左炔诺孕酮)、环孢菌素、克莫司和西沙比利. 这些相互作用通常被观察到的高剂量的氟康唑(200毫克/日或更多)。

管理：谨慎建议时，氟康唑是使用药物，经过新陈代谢通过CYP450 3A4，特别是那些与一个狭窄的治疗范围。量的调整以及临床和实验室监控可以适用于某些药物只要氟康唑是加入或撤离治疗。

来源

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