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Diflucan (Fluconazole Tablets) 与 Sandimmune (Cyclosporine Oral Solution)

Diflucan (Fluconazole Tablets) 与 Sandimmune (Cyclosporine Oral Solution)互相作用以及同时服用的可能性。

检测结果:

Diflucan (Fluconazole Tablets) <> Sandimmune (Cyclosporine Oral Solution)

现实性: 26.01.2023 评论家: 医学副博士Shkutko P.M., in

在该服务的官方手册中，已注明相关研究结果统计规定的互相作用。该互相作用或对患者健康引起不良后果，或起到良好效果。具体联合用药问题，需遵从医嘱。

用户:

使用药与氟康唑可能增加的影响环孢菌素。联系您的医生，如果你遇到恶心、呕吐、腹泻、腹部疼痛、疲劳或头痛的问题。如果你的医生开的这些药物在一起，可能需要的剂量调整或特别的测试安全地使用这两种药物。重要的是要告诉你的医生关于所有其他药物的使用，包括维生素和草药。不停止使用任何药物，没有第一个说你的医生。

医界专家:

监视器：氟康唑可能会抑制CYP450 3A4肝脏和/或肠壁的新陈代谢的环孢菌素。血清孢菌素浓度和风险的毒性可能会增加，虽然数据是相互矛盾的。这种相互作用更有可能用更高剂量的氟康唑(超过200毫克/天)。

管理：如果伴随治疗是必需的，血清cyclosporine的水平和肾功能应密切监测。量的调整可能是必需的。患者应建议通知他们的医生如果他们遇到恶心、呕吐、腹泻、腹部疼痛、疲劳或头痛的问题。

来源

Kruger HU, Schuler U, Zimmerman R, Ehninger G "Absence of significant interaction of fluconazole with cyclosporin." J Antimicrob Chemother 24 (1989): 781-6
Osowski CL, Dix SP, Lin LS, Mullins RE, Geller RB, Wingard JR "Evaluation of the drug interaction between intravenous high-dose fluconazole and cyclosporine or tacrolimus in bone marrow transplant patients." Transplantation 61 (1996): 1268-72
Back D, Tjia J "Comparative effects of the antimycotic drugs ketoconazole, fluconazole, itraconazole and terbinafine on the metabolism of cyclosporin by human liver microsomes." Br J Clin Pharmacol 32 (1991): 624-6
Sugar AM, Saunders C, Idelson BA, Bernard DB "Interaction of fluconazole and cyclosporine." Ann Intern Med 110 (1989): 844
Canafax DM, Graves NM, Hilligoss DM, Carleton BC, Gardner MJ, Matas AJ "Increased cyclosporine levels as a result of simultaneous fluconazole and cyclosporine therapy in renal transplant recipients: a double-blind, randomized pharmacokinetic and safety study." Transplant Proc 23 (1991): 1041-2
Lopez-Gil JA "Fluconazole-cyclosporin interaction: a dose-dependent effect?" Ann Pharmacother 27 (1993): 427-30
Torregrosa V, De la Torre M, Campistol JM, et al "Interaction of fluconazole with ciclosporin A." Nephron 60 (1992): 125-6
Ehninger G, Jaschonek K, Schuler U, Kruger HU "Interaction of fluconazole with cyclosporin." Lancet 2 (1989): 104-5
Canafax DM, Graves NM, Hilligoss DM, et al "Interaction between cyclosporine and fluconazole in renal allograft recipients." Transplantation 51 (1991): 1014-8
"Product Information. Sandimmune (cyclosporine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.