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Methylergonovine oral and injection 与 Serzone

Methylergonovine oral and injection 与 Serzone互相作用以及同时服用的可能性。

检测结果:

Methylergonovine oral and injection <> Serzone

现实性: 01.10.2022 评论家: 医学副博士Shkutko P.M., in

在该服务的官方手册中，已注明相关研究结果统计规定的互相作用。该互相作用或对患者健康引起不良后果，或起到良好效果。具体联合用药问题，需遵从医嘱。

用户:

使用methylergonovine一起奈法唑酮，不建议。结合这些药物可以大大增加，血液水平和效果的methylergonovine，这在某些情况下可能导致过度缩小血管的身体。这可以降低血液流向重要机构，并增加的风险罕见的，但是严重的副作用，例如高血压、心脏病、中风、坏疽和(死亡的组织，通常在胳膊或一条腿，可能需要外科手术截肢). 谈谈你的医生如果你有任何疑问或关切的问题。你的医生可以规定替代品，不进行互动。你应该立即寻求医疗照顾，如果你经历剧烈的腹痛、恶心、呕吐，麻木或刺痛、肌肉疼痛或疲软、蓝色和紫色的手或脚的，苍白的，或冷的皮肤、胸部疼痛或密性，心跳不规则，严重头痛、呼吸急促、视力模糊、混乱、和/或含糊不清的语音治疗期间methylergonovine. 不采取更大剂量使用或使用药物的频率比的规定。重要的是要告诉你的医生关于所有其他药物的使用，包括维生素和草药。不停止使用任何药物，没有第一个说你的医生。

医界专家:

禁忌:共同给予与奈法唑酮可能会显着增加的等离子浓度的麦角衍生物。该机制涉及奈法唑酮抑制CYP450 3A4，同工酶负责代谢清除麦角胺和有关的药物。虽然相互作用没有被具体地研究了与奈法唑酮，它已经发生在患者接受麦角胺或双氢麦角胺与其他有效的CYP450 3A4抑制剂，如大环内酯类抗生素和蛋白酶抑制剂。临床ergotism已有报道，这可能会导致坏疽和心肌梗死在严重的情况下。即使是小的、单剂量的麦角胺导致临床显着的相互作用，偶尔造成外科手术截肢或死亡。此外，某些麦角生物碱如麦角胺和双氢麦角胺拥有素的活动。共同给予与奈法唑酮，也有素的代理，可能会使可能的风险的血清素综合症，这是一个罕见的，但是严重的和潜在的致命状况的思想导致过度刺激的脑干5-HT1A和2A受体。症状的血清素综合征可以包括精神状态的变化，例如烦躁、改变的意识，混淆，幻觉和昏迷;自主神经功能障碍如性心动过速、热疗、发汗解表、颤抖、血压不稳定，并散瞳;神经肌肉异常比如反射亢进、肌阵挛、震颤、刚性，并共济失调；和胃肠道症状，例如腹部绞痛、恶心、呕吐、腹泻。

管理：鉴于潜在的用麦角毒性特征的周边血管痉挛、局部缺血、血栓、心动过速和高血压，同时使用奈法唑酮用麦角衍生物视为禁忌。伴随使用麦角胺或双氢麦角胺具体来说可能是相关联的附加风险的血清素综合症。

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