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Moxifloxacin Tablets 与 Warfarin

Moxifloxacin Tablets 与 Warfarin互相作用以及同时服用的可能性。

检测结果:

Moxifloxacin Tablets <> Warfarin

现实性: 21.12.2022 评论家: 医学副博士Shkutko P.M., in

在该服务的官方手册中，已注明相关研究结果统计规定的互相作用。该互相作用或对患者健康引起不良后果，或起到良好效果。具体联合用药问题，需遵从医嘱。

用户:

用莫西沙星一起华法林可能会导致你流血更容易。你可能需要调整剂量的基础上你的凝血酶原时间或国际标准化比率(印度). 叫你的医生及时如果你有任何不寻常或出血瘀伤、呕吐、血液在你的尿液或凳子、头疼、头晕、或弱点。重要的是要告诉你的医生关于所有其他药物的使用，包括维生素和草药。不停止使用任何药物，没有第一个说你的医生。

医界专家:

密切监测：某些酮类抗生素已经报告了促进hypoprothrombinemic效华法林和其他香豆素抗凝血剂。的确切机制是未知的，但可能涉及的抑制香豆素的新陈代谢和/或耗竭的某些凝血因子由于抑制维生素K产肠菌群。回顾队列研究的急性病药物的患者在一个美国老兵事务医疗中心透露的风险增加和严重程度overanticoagulation下发起的左氧氟沙星相比，控制剂，特拉唑. 具体而言，意味着卢比增加的0.85观察到的左氧氟沙星组(n=27个)，相比平均下降的0.15在特拉唑组(n=29条)。海拔在印度卢比超出治疗水平都看到，在33%左氧氟沙星的病人比5%的特拉唑患者，以及印度卢比的海拔超过4们看到的19％左氧氟沙星患者和0％的特拉唑患者(后者没有统计上的显着)。同样，基于人口的队列研究注重于抗生素的使用在门诊病人治疗与phenprocoumon或醋硝香豆素在荷兰的抗凝血诊所确定的诺氟沙星使用的危险因素overanticoagulation(印度卢比等于或大于6)，即使在调整潜在混淆的因素。也有的情况下报告的主要是老年患者中稳定在华法林是谁发展PT或卢比的增加和/或出血并发症以下另外一个诺酮. 增加的印度卢比值一般观察到在2至16日下发起的诺酮治疗。环丙沙星，依诺沙星,沙星、左氧氟沙星、莫西沙星、萘啶酸、诺氟沙星、氧氟沙星，并曲伐已经具体的牵连。 1987年和1997年，美国食品和药物管理局收到了66报告的情况下可疑的交互作用涉及环丙沙星的单。作为一月至2004年，加拿大卫生部收到了57份报告(左氧氟沙星16;沙星13个；莫西沙星12;环丙沙星10;诺氟沙星6)，其中包括四人死亡，涉及的沙星(2)、环丙沙星(1)，与左氧氟沙星(1)条。但是，因不能成立，因为多混杂的因素。在一般情况下，数据临床研究的各种药物有不支持的一个重大的、可预测的药效动力学或药物动力学的相互作用与华法林. 然而，潜在的交易感患者不能排除出去。其他因素影响，例如热病、感染、营养不良和其它伴随的基本条件上的凝血机制和华法林的药物动力学也应该予以考虑。

管理：考虑到临床明显的相互作用，甚至死亡的偶然的，容易受病人，密切监测是建议，如果一个诺酮的抗生素是规定在香豆素抗凝血剂的治疗。印度卢比应进行检查，经常与香豆素的剂量进行相应的调整，特别是以下启动或中止的诺酮治疗的病人稳定对他们的抗凝血剂方案。患者应立即报告任何出血的迹象到他们的医生，包括疼痛、肿、头疼、头晕、弱点、出血时间延长，从削减，增加经流，阴道出血、流鼻血，止血的牙龈刷、不寻常或出血瘀伤、红色或棕色的尿液或红色或黑色的大便。同样的预防措施可以是适用治疗期间其它口腔抗凝血剂(例如，indandiones)，虽然临床数据缺乏。

来源

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