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Sandimmune (Cyclosporine Oral Solution) 与 Verapamil oral/injection

Sandimmune (Cyclosporine Oral Solution) 与 Verapamil oral/injection互相作用以及同时服用的可能性。

检测结果:

Sandimmune (Cyclosporine Oral Solution) <> Verapamil oral/injection

现实性: 09.04.2023 评论家: 医学副博士Shkutko P.M., in

在该服务的官方手册中，已注明相关研究结果统计规定的互相作用。该互相作用或对患者健康引起不良后果，或起到良好效果。具体联合用药问题，需遵从医嘱。

用户:

使用药与维拉帕米可能增加的效果的药并造成危害的肾脏。症状的肾脏损坏包括肿胀，重量增益，感觉，呼吸短促，嗜睡，混乱，情绪变化，增加的口渴、食欲丧失、恶心和呕吐，疼痛在你后背下，排尿或多或少比平常或没有。如果你采取这两种药物在一起，告诉医生，如果你有任何的这些症状。你可能需要的剂量调整或特别的测试安全地使用这些药物在一起。重要的是要告诉你的医生关于所有其他药物的使用，包括维生素和草药。不停止使用任何药物，没有第一个说你的医生。

医界专家:

监视器：维拉帕米可能会抑制CYP450 3A4肝新陈代谢的环孢菌素。槽和稳定状态的级别和肾毒性的风险可能会增加。

管理：Cyclosporine的水平和肾功能应该进行监测，并且剂量应根据需要进行调整，并在适当的治疗。其他钙通道阻断剂，具有较小影响孢菌素的新陈代谢也可以考虑作为替代办法(例如，地平,伊拉地平、硝苯地平，尼群地).

来源

Jacobs U, Klein B, Klehr HU "Cumulative side effects of cyclosporine and ca antagonists: hypergalactinemia, mastadenoma, and gynecomastia." Transplant Proc 26 (1994): 3122
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Sketris IS, Methot ME, Nicol D, Belitsky, Knox MG "Effect of calcium-channel blockers on cyclosporine clearance and use in renal transplant patients." Ann Pharmacother 28 (1994): 1227-31
Dy GR, Raja RM, Mendez MM "The clinical and biochemical effect of calcium channel blockers in organ transplant recipients on cyclosporine." Transplant Proc 23 (1991): 1258-9
Robson RA, Fraenkel M, Barratt LJ, Birkett DJ "Cyclosporin-verapamil interaction." Br J Clin Pharmacol 25 (1988): 402-3
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Sketris IS, Methot ME, Nicol D, Belitsky P, Knox MG "Effect of calcium-channel blockers on cyclosporine clearance and use in renal transplant patients." Ann Pharmacother 28 (1994): 1227-31
Dawidson I, Rooth P, Fry WR, et al "Prevention of acute cyclosporine-induced renal blood flow inhibition and improved immunosuppression with verapamil." Transplantation 48 (1989): 575-80
Dawidson I, Rooth P, Alway C, et al "Verapamil prevents posttransplant delayed function and cyclosporine A nephrotoxicity." Transplant Proc 22 (1990): 1379-80
Tortorice KF, Heim-Duthoy KL, Awni WM, Rao KV, Kasiske BL "The effects of calcium channel blockers on cyclosporine and its metabolites in renal transplant recipients." Ther Drug Monit 12 (1990): 321-8
Yildiz A, Sever MS, Turkman A, Ecder T, Turk S, Akkaya V, Ark E "Interaction between cyclosporine A and verapamil, felodipine, and isradipine." Nephron 81 (1999): 117-8