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Abiraterone 与 Dihydroergotamine injection

Abiraterone 与 Dihydroergotamine injection互相作用以及同时服用的可能性。

检测结果:

Abiraterone <> Dihydroergotamine injection

现实性: 10.12.2022 评论家: 医学副博士Shkutko P.M., in

在该服务的官方手册中，已注明相关研究结果统计规定的互相作用。该互相作用或对患者健康引起不良后果，或起到良好效果。具体联合用药问题，需遵从医嘱。

用户:

阿比特龙可能增加的血液水平和效果的双氢麦角胺，这在某些情况下可能导致过度缩小血管的身体。这可以降低血液流向重要机构，并增加的风险罕见的，但是严重的副作用，例如高血压、心脏病、中风、坏疽和(死亡的组织，通常在胳膊或一条腿，可能需要外科手术截肢). 谈谈你的医生如果你有任何疑问或关切的问题。你的医生可以规定替代品，不进行互动，或者可能需要一剂量的调整或更频繁的监测安全地使用这两种药物。你应该立即寻求医疗照顾，如果你经历剧烈的腹痛、恶心、呕吐，麻木或刺痛、肌肉疼痛或疲软、蓝色和紫色的手或脚的，苍白的，或冷的皮肤、胸部疼痛或密性，心跳不规则，严重头痛、呼吸急促、视力模糊、混乱、和/或含糊不清的语音治疗期间，双氢麦角胺. 不采取更大剂量使用或使用药物的频率比的规定。重要的是要告诉你的医生关于所有其他药物的使用，包括维生素和草药。不停止使用任何药物，没有第一个说你的医生。

医界专家:

监视器：共同给予的抑制剂CYP450 3A4可能增加等离子浓度的麦角衍生物，其主要代谢的同工酶. 相互作用已经发生在患者接受麦角胺或双氢麦角胺有效CYP450 3A4抑制剂，如大环内酯类抗生素和蛋白酶抑制剂。临床ergotism已有报道，这可能会导致坏疽和心肌梗死在严重的情况下。即使是小的、单剂量的麦角胺导致临床显着的相互作用，偶尔造成外科手术截肢或死亡。没有数据可用于其他不太有效的CYP450 3A4抑制剂。

管理：谨慎建议期间同时使用麦角衍生物的轻度或中度CYP450 3A4抑制剂。应监测患者的潜在麦角毒性包括外周血管痉挛、局部缺血、血栓、心动过速和高血压。

来源

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