根据名称进行药物检索

Acetaminophen, Aspirin, Caffeine, and Salicylamide Tablets 与 Monopril

Acetaminophen, Aspirin, Caffeine, and Salicylamide Tablets 与 Monopril互相作用以及同时服用的可能性。

检测结果:

Acetaminophen, Aspirin, Caffeine, and Salicylamide Tablets <> Monopril

现实性: 16.05.2022 评论家: 医学副博士Shkutko P.M., in

在该服务的官方手册中，已注明相关研究结果统计规定的互相作用。该互相作用或对患者健康引起不良后果，或起到良好效果。具体联合用药问题，需遵从医嘱。

用户:

之前把阿司匹林，告诉医生，如果你还利用福辛普利. 你可能需要的剂量调整或特别的测试，以便安全地把这两种药物在一起。如果你正在接受治疗与这种组合你应该检查你的血压力和可能需要你的肾功能的监测。重要的是要告诉你的医生关于所有其他药物的使用，包括维生素和草药。不停止使用药物而不首先说你的医生第一次。

医界专家:

监测：某些调查表明，共同给予有阿司匹林可能衰减的血管扩张剂和低血压的影响ACE抑制剂。此外，一些已发现的利益ACE抑制剂有关的发病率和死亡率的后急性心肌梗塞、冠状动脉心脏病，特别是充血性心力衰竭可能会受到损害或甚至无效的阿司匹林。拟议的机制是阿司匹林环氧化酶抑制，导致制止前列腺素的综合和前列腺素介导的血液动力学影响的王牌的抑制剂。然而，证据的一个负面的相互作用很大程度上是相互矛盾，并解释相关的数据往往是复杂的多混杂的因素，以及追溯性或事后性质的大多数研究。提供的数据似乎表明低剂量的阿司匹林药(小于236毫克/日，而尤其是小于100毫克/日)是不可能的，或至少明显不太可能，干扰与ACE抑制剂的作用，虽然敏感性的相互作用可能会受到一定程度的interpatient的可变性。

管理：根据目前的数据，难以确定可能性的一个负面的相互作用之间的阿司匹林和ACE抑制剂和其的临床相关性长期治疗，特别是在充血性心力衰竭。目前的建议通常并不排除合用于患有心血管疾病的风险因素，否则可能受益于药物的独立。然而，患者接受长期治疗的组合应该进行定期的血压和其他适当的临床监测，如肾功能评估。最低的治疗剂量的阿司匹林应可使用。

来源

The Heart Outcomes Prevention Evaluation Study Investigators "Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients." N Engl J Med 342 (2000): 145-53
Nawarskas JJ, Spinler SA "Update on the interaction between aspirin and angiotensin-converting enzyme inhibitors." Pharmacotherapy 20 (2000): 698-710
Silberbauer K, Stanek B, Templ H "Acute hypotensive effect of captopril in man modified by prostaglandin synthesis inhibition." Br J Clin Pharmacol 14 (1982): s87-93
Kober L, Torp-Pedersen C, Carlsen JE, Bagger H, Eliasen P, Lyngborg K, Videbaek J, Cole DS, Auclert L, Pauly NC, et al "A clinical trial of the angiotensin-converting-enzyme inhibitor trandolapril in patients with left ventricular dysfunction after myocardial infarction. Trandolapril Cardiac Evaluation (TRACE) Study Group." N Engl J Med 333 (1995): 1670-6
Moore TJ, Crantz FR, Hollenberg NK "Contribution of prostaglandins to the antihypertensive action of captopril in essential hypertension." Hypertension 3 (1981): 168-73
Mahe I, Meune C, Diemer M, Caulin C, Bergmann JF "Interaction between aspirin and ACE inhibitors in patients with heart failure." Drug Saf 24 (2001): 167-82
Ahmed A "Interaction between aspirin and angiotensin-converting enzyme inhibitors: should they be used together in older adults with heart failure?" J Am Geriatr Soc 50 (2002): 1293-6
Oosterga M, Anthonio RL, deKam PJ, Kingma JH, Crijns HJGM, vanGilst WH "Effects of aspirin on angiotensin-converting enzyme inhibition and left ventricular dilation one year after acute myocardial infarction." Am J Cardiol 81 (1998): 1178-81
Spaulding C, Charbonnier B, CohenSolal A, Juilliere Y, Kromer EP, Benhamda K, Cador R, Weber S "Acute hemodynamic interaction of aspirin and ticlopidine with enalapril: Results of a double-blind, randomized comparative trial." Circulation 98 (1998): 757-65
Hall D, Zeitler H, Rudolph W "Counteraction of the vasodilator effects of enalapril by aspirin in severe heart failure." J Am Coll Cardiol 20 (1992): 1549-55
Massie BM, Teerlink JR "Interaction between aspirin and angiotensin-converting enzyme inhibitors: Real or imagined." Am J Med 109 (2000): 431-3
Meune C, Mahe I, Mourad JJ, Simoneau G, Knellwolf AL, Bergmann JF, Caulin C "Interaction between angiotensin-converting enzyme inhibitors and aspirin: a review." Eur J Clin Pharmacol 56 (2000): 609-20
Acute Infarction Ramipril Efficacy (AIRE) Study Investigators "Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure." Lancet 342 (1993): 821-8
Zanchetti A, Hansson L, Leonetti G, et al. "Low-dose aspirin does not interfere with the blood pressure-lowering effects of antihypertensive therapy." J Hypertens 20 (2002): 1015-1022
Guazzi M, Brambilla R, Reina G, Tumminello G, Guazzi MD "Aspirin-angiotensin-converting enzyme inhibitor coadministration and mortality in patients with heart failure: a dose-related adverse effect of aspirin." Arch Intern Med 163 (2003): 1574-9
Leor J, ReicherReiss H, Goldbourt U, Boyko V, Gottlieb S, Battler A, Behar S "Aspirin and mortality in patients treated with angiotensin-converting enzyme inhibitors - A cohort study of 11,575 patients with coronary artery disease." J Am Coll Cardiol 33 (1999): 1920-5
Nawarskas JJ, Spinler SA "Does aspirin interfere with the therapeutic efficacy of angiotensin-converting enzymen inhibitors in hypertension or congestive heart failure?" Pharmacotherapy 18 (1998): 1041-52
Polonia J, Boaventura I, Gama G, Camoes I, Bernardo F, Andrade P, Nunes JP, Brandao F, Cerqueiragomes M "Influence of non-steroidal anti-inflammatory drugs on renal function and 24h ambulatory blood pressure-reducing effects of enalapril and nifedipine gastrointestinal therapeutic system in hypertensive patients." J Hypertens 13 (1995): 925-31
Nguyen KN, Aursnes I, Kjekshus J "Interaction between enalapril and aspirin on mortality after acute myocardial infarction: subgroup analysis of the cooperative new scandinavian enalapril survival study II (CONSENSUS II)." Am J Cardiol 79 (1997): 115-9
Teo K, Yusuf S, Pfeffer M, et al. "Effects of long-term treatment with angiotensin-converting-enzyme inhibitors in the presence or absence of aspirin: a systematic review." Lancet 360 (2002): 1037
Pfeffer MA, Braunwald E, Moye LA, et al "Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction: results of the Survival and Ventricular Enlargement Trial." N Engl J Med 327 (1992): 669-77
Song KH, Fedyk R, Hoover R "Interaction of ACE inhibitors and aspirin in patients with congestive heart failure." Ann Pharmacother 33 (1999): 375-7
Lapane KL, Hume AL, Barbour MM, Lipsitz LA "Does aspirin attenuate the effect of angiotensin-converting enzyme inhibitors on health outcomes of very old patients with heart failure?" J Am Geriatr Soc 50 (2002): 1198-204