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Adalat CC 与 Alfentanil Intravenous

Adalat CC 与 Alfentanil Intravenous互相作用以及同时服用的可能性。

检测结果:

Adalat CC <> Alfentanil Intravenous

现实性: 05.12.2022 评论家: 医学副博士Shkutko P.M., in

在该服务的官方手册中，已注明相关研究结果统计规定的互相作用。该互相作用或对患者健康引起不良后果，或起到良好效果。具体联合用药问题，需遵从医嘱。

用户:

硝苯地平可能增加的血液水平的芬太尼. 这可能增加风险和/或严重性的副作用，如过度镇静、呼吸抑郁症低血压和非正规心脏的节奏。你可能需要的剂量调整到安全地使用这两种药物。谈谈你的医生如果你有任何疑问或关切的问题。重要的是要告诉你的医生关于所有其他药物的使用，包括维生素和草药。不停止使用任何药物，没有第一个说你的医生。

医界专家:

监视器：共同给予的抑制剂CYP450 3A4可能增加等离子浓度的芬太尼，其主要代谢的同工酶. 阿芬太尼清除已被报道大幅度减少在存在中度或有效的抑制剂的CYP450 3A4如替丁、硫氮、氟康唑，并醋竹桃霉素. 孤立的报告的长期的镇静和呼吸抑郁症也已经与同时使用的抑制剂，如红霉素。

管理：患者接受阿芬太尼结合CYP450 3A4抑制剂应当仔细监测用于过多的中枢神经系统和呼吸抑郁症，并且剂量调整因此，如果有必要的。恢复时间从阿芬太尼麻醉可以延长在某些情况下。

来源

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