根据名称进行药物检索

Afeditab CR 与 Cimetidine Oral Solution

Afeditab CR 与 Cimetidine Oral Solution互相作用以及同时服用的可能性。

检测结果:

Afeditab CR <> Cimetidine Oral Solution

现实性: 21.12.2023 评论家: 医学副博士Shkutko P.M., in

在该服务的官方手册中，已注明相关研究结果统计规定的互相作用。该互相作用或对患者健康引起不良后果，或起到良好效果。具体联合用药问题，需遵从医嘱。

用户:

替丁可以增加血液水平和效果的硝苯地平。这可能会增加风险的严重副作用，例如非正规心脏的节奏，液体潴留，肿胀，心脏衰竭和过度低血压。你应该立即寻求医疗照顾，如果你的经验，突然的，无法解释的重量增益；肿胀的手、脚或脚；头晕、头晕或晕倒;呼吸困难；胸痛苦或密封性；或不规则或减缓心跳在处理与这些药物。你可能需要的剂量调整或更频繁的监测通过你的医生到安全地使用这两种药物。你的医生或药剂师也可能建议的替代替丁，你可以安全地使用用硝苯地平。避免开车或操作危险机械的直到你知道如何药物影响你和谨慎使用当得到了从一个坐在或卧位。重要的是要告诉你的医生关于所有其他药物的使用，包括维生素和草药。不停止使用任何药物，没有第一个说你的医生。

医界专家:

监视器：共同给予与替丁可能增加等离子浓度的钙通道阻断剂，这是基于CYP450 3A4同工酶. 该机制降低清关，由于抑制CYP450 3A4活动通过替丁.

管理：密切监测临床反应和容忍的建议，如果替丁结合使用钙通道阻断剂，是代谢通过CYP450 3A4如硫、非洛地平、尼卡地平、硝苯地平、尼莫地平、尼索，并维拉帕米。剂量减少40%至50%可以认为，如果有必要的。病人应被告知寻求医疗注意，如果他们遇到水肿或肿胀的下肢;突然，原因不明的重量增益；呼吸困难；胸痛苦或密封性；或低血压如由头晕晕倒，或orthostasis. 其他H2-受体拮抗剂可能更安全的替代品，因为它们没有显示出明显影响CYP450 3A4的新陈代谢。然而，有的已经分离的报告之间的相互作用此药物和钙通道阻断，包括硝苯地平和尼群地.

来源

"Product Information. Sular (nisoldipine)." Zeneca Pharmaceuticals, Wilmington, DE.
Smith SR, Kendall MJ, Lobo J, Beerahee A, Jack DB, Wilkins MR "Ranitidine and cimetidine; drug interactions with single dose and steady-state nifedipine administration." Br J Clin Pharmacol 23 (1987): 311-5
Mikus G, Eichelbaum M, Fischer C, et al "Interaction of verapamil and cimetidine: stereochemical aspects of drug metabolism, drug disposition and drug action." J Pharmacol Exp Ther 253 (1990): 1042-8
Muck W, Wingender W, Seiberling M, Woelke E, Ramsch KD, Kuhlmann J "Influence of the H2-receptor antagonists cimetidine and ranitidine on the pharmacokinetics of nimodipine in healthy volunteers." Eur J Clin Pharmacol 42 (1992): 325-8
Smith MS, Benyunes MC, Bjornsson TD, et al "Influence of cimetidine on verapamil kinetics and dynamics." Clin Pharmacol Ther 36 (1984): 551-4
Smith SR, Kendall MJ, Lobo J, et al "Ranitidine and cimetidine; drug interactions with single dose and steady-state nifedipine administration." Br J Clin Pharmacol 23 (1987): 311-5
Winship LC, McKenney JM, Wright JT, Wood JH, Goodman RP "The effect of ranitidine and cimetidine on single-dose diltiazem pharmacokinetics." Pharmacotherapy 5 (1985): 16-9
Schwartz JB, Upton RA, Lin ET, Willias RL, Benet LZ "Effect of cimetidine or ranitidine administration on nifedipine pharmacokinetics and pharmacodynamics." Clin Pharmacol Ther 43 (1988): 673-80
Renwick AG, Le Vie J, Challenor VF, Waller DG, Gruchy B, George CF "Factors affecting the pharmacokinetics of nifedipine." Eur J Clin Pharmacol 32 (1987): 351-5
Janzon K, Edgar B, Lundborg P, Regardh CG "The influence of cimetidine and spironolactone on the pharmacokinetics and haemodynamic effects of felodipine in healthy subjects." Acta Pharmacol Toxicol (Copenh) 59 (1986): 98
Kirch W, Hutt HJ, Heidemann H, et al "Drug interactions with nitrendipine." J Cardiovasc Pharmacol 6 (1984): s982-5
Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]):
Loi CM, Rollins DE, Dukes GE, Peat MA "Effect of cimetidine on verapamil disposition." Clin Pharmacol Ther 37 (1985): 654-7
Wing LM, Miners JO, Lillywhite KJ "Verapamil disposition: effects of sulphinpyrazone and cimetidine." Br J Clin Pharmacol 19 (1985): 385-91
Kirch W, Ramsch K, Janisch HD, Ohnhaus EE "The influence of two histamine H2-receptor antagonists, cimetidine and ranitidine, on the plasma levels and clinical effect of nifedipine and metoprolol." Arch Toxicol Suppl 7 (1984): 256-9
Khan A, Langley SJ, Mullins FG, Dixon JS, Toon S "The pharmacokinetics and pharmacodynamics of nifedipine at steady state during concomitant administration of cimetidine or high dose ranitidine." Br J Clin Pharmacol 32 (1991): 519-22