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Alimta 与 Excedrin Back & Body

Alimta 与 Excedrin Back & Body互相作用以及同时服用的可能性。

检测结果:

Alimta <> Excedrin Back & Body

现实性: 24.06.2022 评论家: 医学副博士Shkutko P.M., in

在该服务的官方手册中，已注明相关研究结果统计规定的互相作用。该互相作用或对患者健康引起不良后果，或起到良好效果。具体联合用药问题，需遵从医嘱。

用户:

使用培美曲塞在一起，与阿司匹林可能增加的影响的培美曲塞. 联系您的医生，如果你经验的热、冷、身体疼痛，流感的症状、口疮或白色斑块，严重腹泻。培美曲塞可以降低血细胞，帮助你的身体抵抗感染。这可以使它更容易让你流血受伤或得病被周围的人都生病了。可以肯定的是你的血细胞得不到太低的，你的血液中将需要进行测试，在定期的基础上。如果你的医生，并规定这些药物在一起，可能需要的剂量调整或特别的测试安全地使用这两种药物。重要的是要告诉你的医生关于所有其他药物的使用，包括维生素和草药。不停止使用任何药物，没有第一个说你的医生。

医界专家:

调整配量的时间间隔：共同给予与非甾体抗炎药(非甾体抗炎药)的可能增加等离子浓度的培美曲塞. 该机制没有描述，但可能与非甾体抑制肾前列腺素. 使用的药物已经与肾病有关的表现为海拔在血清肌酸酐和面包，管坏死，glomerulitis、肾乳头坏死、急性间质性肾炎、肾病综合症和肾衰竭。由于培美曲塞主要是消除不变的肾脏排泄，共同给予与非甾体抗炎药可能导致延迟和/或减少的间隙。每日的剂量服用布洛芬的400毫克每天四次已经显示出为减少培美曲塞清除了约20％，在患者正常肾功能，而阿司匹林在325毫克每6小时都没有。效果的高剂量服用布洛芬或阿司匹林是未知的。

管理：布洛芬至400毫克和阿司匹林在325毫克每天四次，或更少，可以用于与培美曲塞在患者正常肾功能。然而，谨慎建议在患有轻度至中度的肾功能衰竭(肌酸酐清45至79毫升/分钟)。这些患者应该避免采取非甾体抗炎药的短消除半衰期(例如，芬酸，酸、非诺洛芬、芬、布洛芬、消炎痛、洛芬、酮咯酸、meclofenamate、甲灭酸、舒,托美丁、低剂量的水杨酸盐)2天之前2天后培美曲塞管理。如果伴随的管理是必要的，患者应该密切监视为毒性，尤其是骨髓抑制、肾毒性，和胃肠毒性。在没有相关数据的使用与药物有较长的半衰期，预扣非甾体的配量至少5天之前2天后管理培美曲塞建议。

来源

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