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Altoprev 与 PCE Dispertab

Altoprev 与 PCE Dispertab互相作用以及同时服用的可能性。

检测结果:
Altoprev <> PCE Dispertab
现实性: 16.08.2022 评论家: 医学副博士Shkutko P.M., in

在该服务的官方手册中，已注明相关研究结果统计规定的互相作用。该互相作用或对患者健康引起不良后果，或起到良好效果。具体联合用药问题，需遵从医嘱。

用户:

使用红霉素一起洛伐他不建议。 结合这些药物可以大大增加，血液水平的洛伐他. 这可能增加风险的副作用，例如肝脏损坏和一个罕见的，但严重的情况称为横纹肌瘤，涉及到崩溃的骨骼肌肉组织。 在某些情况下，横纹肌瘤可造成肾脏损伤甚至死亡。 你可能需要的剂量调整或更频繁的监测通过你的医生，安全地使用这两种药物，或者你的医生可以规定替代药物，即不要相互作用。 让你的医生立即知道如果你有无法解释的肌肉疼痛、温柔、或弱点在处理与洛伐他或类似的药物，尤其是如果这些症状是伴随着发烧或暗色的尿液。 你也应该立即寻求医疗照顾，如果你开发的热、冷、关节疼痛或肿胀、不寻常或出血瘀伤、皮疹、瘙痒，食欲不振、疲劳、恶心、呕吐、暗色的尿液和/或黄皮肤或眼睛，因为这些可能的迹象和症状的肝脏损伤。 重要的是要告诉你的医生关于所有其他药物的使用，包括维生素和草药。 不停止使用任何药物，没有第一个说你的医生。

医界专家:

禁忌:共同给予有效抑制剂的CYP450 3A4可能会显着增加的等离子浓度的伐他汀和洛伐他和他们的活动酸代谢物，所有这些都是主要代谢的同工酶. 相互作用已经报告了与强大的CYP450 3A4抑制剂，如唑抗真菌剂、大环内酯类抗生素、艾滋病毒蛋白酶抑制剂，并奈法唑酮. 临床上，高级别的英国政府CoA还原酶抑制活动的血浆可能是相关的风险增加的骨骼肌肉毒性。 肌病表现为肌肉疼痛和/或弱点相关的严重升高的肌酸激酶超过十倍正常上限已经报道的偶尔。 横纹肌瘤也已发生很少，这可能是伴随着急性肾功能衰竭次要myoglobinuria，并可能导致死亡。

管理：由于潜在的严重的相互作用，同时使用的伐他汀或洛伐他与有效的CYP450 3A4抑制剂被认为是禁忌。 氟伐,普,匹伐他，并伐他汀可能更安全的替代品，因为它们不是代谢通过CYP450 3A4. 所有患者接受汀治疗应立即报告任何无法解释的肌肉疼痛、温柔弱，尤其是如果伴随高烧、不适和/或暗色的尿液。 治疗应该停止，如果肌酸磷酸激酶是明显升高，在没有剧烈的运动或者如果肌病是无怀疑或诊断。

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Altoprev

非专利名称: lovastatin

品牌: Altoprev, Mevacor, Altocor

同义词: 无

Altoprev是什么？
PCE Dispertab

非专利名称: erythromycin

品牌: EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, E. E. S, EryPed, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV

同义词: PCE Dispertab (Oral), PCE, PCE (Oral)

PCE Dispertab是什么？
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在药物相容性与互相作用的检测过程中使用下列的信息来源：Drugs.com, Rxlist.com, Webmd.com, Medscape.com。

公认药物相互作用的清单
Doktika 和平
与食物，生活方式相互作用
  1. Altoprev
  2. PCE Dispertab
与疾病相互作用
  1. Altoprev
  2. PCE Dispertab