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Blisovi Fe 1/20 与 Mitotane

Blisovi Fe 1/20 与 Mitotane互相作用以及同时服用的可能性。

检测结果:

Blisovi Fe 1/20 <> Mitotane

现实性: 26.12.2023 评论家: 医学副博士Shkutko P.M., in

在该服务的官方手册中，已注明相关研究结果统计规定的互相作用。该互相作用或对患者健康引起不良后果，或起到良好效果。具体联合用药问题，需遵从医嘱。

用户:

米托坦可以降低血液水平和效果的炔雌二醇。如果您使用的低剂量口服避孕药，你可能有风险增加的突破性出血和意外怀孕。你应该讨论使用替代或额外的方法控制生育与您的医疗保健提供者。如果你采取激素替代用于更年期，通知你的医生，如果你的药疗不再控制你的症状或者你的经验异常的流血。你可能需要的剂量调整或更频繁的监测通过你的医生到安全地使用这两种药物。重要的是要告诉你的医生关于所有其他药物的使用，包括维生素和草药。不停止使用任何药物，没有第一个说你的医生。

医界专家:

监视器：共同给予与的诱导剂的CYP450 3A4可能会降低的等离子浓度的雌激素和孕激素。雌激素已经显示在体外和体内的研究可以部分地代谢通过CYP450 3A4和其他类固醇包括孕激素也被认为经过新陈代谢通过此同工酶. 相互作用已经报告的主要用口服避孕药具。已经有情况下，报告的经突破性出血或不想要的怀孕妇女接受低剂量口服避孕药的下列另外的已知CYP450 3A4的诱导剂，如卡马西平，苯巴比妥、苯妥英、利福平,和圣约翰草。反应不足的雌激素替代治疗也已经报道的患者的处理与苯妥英。氨鲁米特，CYP450 3A4诱导剂，已经显示出为减少甲羟孕酮和甲地孕酮的血清水平74%，在六个病人稳定对他们的孕激素的方案。

管理：药物响到雌激素和孕激素应监测更密切地时CYP450 3A4诱加入或撤离治疗、激素的剂量进行调整是必要的。宫内节育系统不大可能显着影响，因为他们的地方行动。输入从一个妇科医生或类似的专家在适当的避孕措施，包括紧急避孕措施，应寻求作为必要的。患者应建议通知他们的医生如果他们的经验不足的控制相关的症状与雌激素缺乏症(例如，夜间汗，血管舒缩干扰，萎缩性阴道炎)或更改该子宫出血的轮廓。

来源

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Blisovi Fe 1/20

非专利名称: ethinyl estradiol / norethindrone

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