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Buprenex injection - Buprenex 与 Zolmitriptan ODT

Buprenex injection - Buprenex 与 Zolmitriptan ODT互相作用以及同时服用的可能性。

检测结果:

Buprenex injection - Buprenex <> Zolmitriptan ODT

现实性: 12.05.2022 评论家: 医学副博士Shkutko P.M., in

在该服务的官方手册中，已注明相关研究结果统计规定的互相作用。该互相作用或对患者健康引起不良后果，或起到良好效果。具体联合用药问题，需遵从医嘱。

用户:

使用丁丙诺啡一起佐米曲坦可能增加风险的一个罕见的，但严重的疾病叫做血清素综合症，其中可能包括的症状，如混乱、幻觉、癫痫、极端变化血压，心率增加、发烧、多汗、颤抖或颤抖、视力模糊，肌肉痉挛或僵硬、震颤、不协调、胃痉挛、恶心、呕吐、腹泻。严重的情况下可能导致昏迷甚至死亡。你应该立即联系你的医生如果你的经验，这些症状的治疗期间。此外，结合这些药物可能增加的副作用，例如头晕、睡，以及难以集中注意力。有些人也可能会遇到一些障碍思考和判断。你应该避免或限制使用酒精，同时正在处理与这些药物。避免开车或操作危险机械的直到你知道如何药物影响你。重要的是要告诉你的医生关于所有其他药物的使用，包括维生素和草药。不停止使用任何药物，没有第一个说你的医生。

医界专家:

监测器：阿片类药物可以增强效果的素的药剂并且增加风险的血清素综合症。相互作用主要是报告与基哌啶阿片类药物(例如哌替啶、芬太尼)和曲马多，这是众所周知具有某种血清素的活动，虽然一些情况下涉及其他阿片类药物，如羟考酮美沙酮、吗啡、氢吗啡、可待因，丁丙诺啡。血清素综合症是一个罕见的，但是严重的和潜在的致命状况的思想导致过度刺激的脑干5-HT1A和2A受体。症状的血清素综合征可以包括精神状态的变化，例如烦躁、改变的意识，混淆，幻觉和昏迷;自主神经功能障碍如性心动过速、热疗、发汗解表、颤抖、血压不稳定，并散瞳;神经肌肉异常比如反射亢进、肌阵挛、震颤、刚性，并共济失调；和胃肠道症状，例如腹部绞痛、恶心、呕吐、腹泻。由于许多羟色剂也可能导致中枢神经系统的抑郁症，伴随使用类鸦片的可能导致增加的镇静作用和损害判断力、思想和精神运动技能。

管理：谨慎建议时，类鸦片使用同时有素的药剂，例如选择性的血清素再吸收抑制剂(Ssri),羟色胺和去甲肾上腺素再吸收抑制剂(它们)，单胺氧化酶抑制剂(单胺氧化抑制剂)、三环抗抑郁药(机师)，其他的抗抑郁药/精神药剂(例如，阿莫沙平、螺环酮、锂、马普替林mirtazepine、奈法唑酮、唑酮、维拉佐酮),5-HT1受体激动剂(曲坦),5-HT3受体拮抗剂，知识产权，右美沙芬,5-羟和圣约翰草。应监测患者症状的血清素综合征治疗期间。特别注意是应当增加剂量的这些试剂。如果血清素综合症的发展或被怀疑在治疗过程中，所有血清素的药剂应当立即停止并支持护理呈现为必要的。适度生病的患者也可以从中受益的管理的一种血清素抗剂(例如，赛庚啶、氯丙嗪). 严重的情况下应该加以管理在咨询与毒物学家并且可能需要镇静剂、神经肌肉麻痹、插管，机械通风除了其他措施。病人也应该被告知潜在的添加剂的中枢神经系统的影响，从这些试剂和避免危险活动需要完整的精神的警觉性和机动的协调，直到他们知道如何使这些代理影响到他们。

来源

Vizcaychipi MP, Walker S, Palazzo M "Serotonin syndrome triggered by tramadol." Br J Anaesth 99 (2007): 919
Shakoor M, Ayub S, Ahad A, Ayub Z "Transient serotonin syndrome caused by concurrent use of tramadol and selective serotonin reuptake inhibitor." Am J Case Rep 15 (2014): 562-4
"Venlafaxine + tramadol: serotonin syndrome." Prescrire Int 13 (2004): 57
Mittino D, Mula M, Monaco F "Serotonin syndrome associated with tramadol-sertraline coadministration." Clin Neuropharmacol 27 (2004): 150-1
Gillman PK "Possible serotonin syndrome with moclobemide and pethidine." Med J Aust 162 (1995): 554
Roy S, Fortier LP "Fentanyl-induced rigidity during emergence from general anesthesia potentiated by venlafexine." Can J Anaesth 50 (2003): 32-5
Guo SL, Wu TJ, Liu CC, Ng CC, Chien CC, Sun HL "Meperidine-induced serotonin syndrome in a susceptible patient." Br J Anaesth (2009):
Kesavan S, Sobala GM "Serotonin syndrome with fluoxetine plus tramadol." J R Soc Med 92 (1999): 474-5
Insler SR, Kraenzler EJ, Licina MG, Savage RM, Starr NJ "Cardiac surgery in a patient taking monoamine oxidase inhibitors - an adverse fentanyl reaction." Anesth Analg 78 (1994): 593-7
Martin TG "Serotonin syndrome." Ann Emerg Med 28 (1996): 520-6
Mateo-Carrasco H, Munoz-Aguilera EM, Garcia-Torrecillas JM, Abu Al-Robb H "Serotonin Syndrome Probably Triggered by a Morphine-Phenelzine Interaction." Pharmacotherapy (2015):
Ailawadhi S, Sung KW, Carlson LA, Baer MR "Serotonin syndrome caused by interaction between citalopram and fentanyl." J Clin Pharm Ther 32 (2007): 199-202
US Food and Drug Administration (FDA) "FDA Drug Safety Communication: FDA warns about several safety issues with opioid pain medicines; requires label changes. Available from: URL: https://www.fda.gov/downloads/Drugs/DrugSafety/UCM491302.pdf." ([2016, Mar 22]):
Gonzalez-Pinto A, Imaz H, De Heredia JL, Gutierrez M, Mico JA "Mania and tramadol-fluoxetine combination. " Am J Psychiatry 158 (2001): 964-5
Lange-Asschenfeldt C, Weigmann H, Hiemke C, Mann K "Serotonin syndrome as a result of fluoxetine in a patient with tramadol abuse: plasma level-correlated symptomatology." J Clin Psychopharmacol 22 (2002): 440-1
Hunter B, Kleinert MM, Osatnik J, Soria E "Serotonergic syndrome and abnormal ocular movements: worsening of rigidity by remifentanil?" Anesth Analg 102 (2006): 1589
Kitson R, Carr B "Tramadol and severe serotonin syndrome." Anaesthesia 60 (2005): 934-5
Egberts AC, ter Borg J, Brodie-Meijer CC "Serotonin syndrome attributed to tramadol addition to paroxetine therapy." Int Clin Psychopharmacol 12 (1997): 181-2
Das PK, Warkentin DI, Hewko R, Forrest DL "Serotonin syndrome after concomitant treatment with linezolid and meperidine." Clin Infect Dis 46 (2008): 264-5
Tissot TA "Probable meperidine-induced serotonin syndrome in a patient with a history of fluoxetine use." Anesthesiology 98 (2003): 1511-1512
Lantz MS, Buchalter EN, Giambanco V "Serotonin syndrome following the administration of tramadol with paroxetine." Int J Geriatr Psychiatry 13 (1998): 343-5
Zornberg GL, Bodkin JA, Cohen BM "Severe adverse interaction between pethidine and selegiline." Lancet 337 (1991): 246
Chan BSH, Graudins A, Whyte IM, Dawson AH, Braitberg G, Duggin GG "Serotonin syndrome resulting from drug interactions." Med J Aust 169 (1998): 523-5
Mahlberg R, Kunz D, Sasse J, Kirchheiner J "Serotonin syndrome with tramadol and citalopram." Am J Psychiatry 161 (2004): 1129
Gnanadesigan N, Espinoza RT, Smith R, Israel M, Reuben DB "Interaction of serotonergic antidepressants and opioid analgesics: Is serotonin syndrome going undetected?" J Am Med Dir Assoc 6 (2005): 265-9
Larson KJ, Wittwer ED, Nicholson WT, Weingarten TN, Price DL, Sprung J "Myoclonus in patient on fluoxetine after receiving fentanyl and low-dose methylene blue during sentinel lymph node biopsy." J Clin Anesth 27 (2015): 247-51
Mason BJ, Blackburn KH "Possible serotonin syndrome associated with tramadol and sertraline coadministration." Ann Pharmacother 31 (1997): 175-7
Houlihan DJ "Serotonin syndrome resulting from coadministration of tramadol, venlafaxine, and mirtazapine." Ann Pharmacother 38 (2004): 411-3
Hillman AD, Witenko CJ, Sultan SM, Gala G "Serotonin syndrome caused by fentanyl and methadone in a burn injury." Pharmacotherapy 35 (2015): 112-7
Sternbach H "The serotonin syndrome." Am J Psychiatry 148 (1991): 705-13
Dougherty JA, Young H, Shafi T "Serotonin syndrome induced by amitriptyline, meperidine, and venlafaxine." Ann Pharmacother 36 (2002): 1647-1648
Hansen TE, Dieter K, Keepers GA "Interaction of fluoxetine and pentazocine." Am J Psychiatry 147 (1990): 949-50
Noble WH, Baker A "MAO inhibitors and coronary artery surgery: a patient death." Can J Anaesth 39 (1992): 1061-6
Rang ST, Field J, Irving C "Serotonin toxicity caused by an interaction between fentanyl and paroxetine." Can J Anaesth 55 (2008): 521-5
Meyer D, Halfin V "Toxicity secondary to meperidine in patients on monoamine oxidase inhibitors: a case report and critical review." J Clin Psychopharmacol 1 (1981): 319-21
Mills KC "Serotonin syndrome: A clinical update." Crit Care Clin 13 (1997): 763
Gillman PK "Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity." Br J Anaesth (2005):
Abadie D, Rousseau V, Logerot S, Cottin J, Montastruc JL, Montastruc F "Serotonin Syndrome: Analysis of Cases Registered in the French Pharmacovigilance Database." J Clin Psychopharmacol (2015):
Rosebraugh CJ, floxkhart DA, Yasuda SU, Woosley RL "Visual hallucination and tremor induced by sertraline and oxycodone in a bone marrow transplant patient." J Clin Pharmacol 41 (2001): 224-7
Davis JJ, Buck NS, Swenson JD, Johnson KB, Greis PE "Serotonin syndrome manifesting as patient movement during total intravenous anesthesia with propofol and remifentanil." J Clin Anesth 25 (2013): 52-4