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Cefixime Oral Suspension 与 Plazomicin

Cefixime Oral Suspension 与 Plazomicin互相作用以及同时服用的可能性。

检测结果:

Cefixime Oral Suspension <> Plazomicin

现实性: 01.11.2022 评论家: 医学副博士Shkutko P.M., in

在该服务的官方手册中，已注明相关研究结果统计规定的互相作用。该互相作用或对患者健康引起不良后果，或起到良好效果。具体联合用药问题，需遵从医嘱。

用户:

Plazomicin可以有时会造成肾脏损伤，并使用头孢菌素的抗生素就像头孢克可能会增加这种风险。谈谈你的医生如果你有任何疑问或关切的问题。你的医生可能已经知道的风险，但是已确定这是最好的治疗并采取适当的预防措施和监控你的密切对任何潜在并发症。迹象和症状的肾脏损伤可能包括恶心、呕吐、食欲不振，增加或减少的排尿、体重突然增加或重量的损耗、液体潴留，肿胀,呼吸困难、肌肉痉挛、疲倦、无力、头晕、混乱和不规则的心脏的节奏。让你的医生知道，如果你遇到的一些或所有这些问题期间的治疗。重要的是要告诉你的医生关于所有其他药物的使用，包括维生素和草药。不停止使用任何药物，没有第一个说你的医生。

医界专家:

监视器：共同给予的这种药物和菌素可能会增加风险的肾毒性。发病率增加的肾毒性已经报告期间同时使用这种药物以及一些，主要是老头孢菌(例如，cefaloridine,头孢孟多,头孢唑啉,头孢噻,头孢西丁、头孢他定,头孢呋,考查,头孢三嗪). 风险可能最大的老年人或患有先前存在的肾损伤，当大剂量使用，并在长时间的治疗。然而，一些研究报告没有不良之间相互作用的某些组合的这些试剂。

管理：最低有效剂量的这种药物和菌素时，应该使用它们的规定相结合。肾功能应该密切监测。同样的预防措施可以适用于当种药物是给予通过灌溉、intrapleurally，腹腔或口头的，因为这种药物可以有系统地吸收了通过这些途径；但是，临床数据缺乏。

来源

Fillastre JP, Laumonier R, Humbert G, et al "Acute renal failure associated with combined gentamicin and cephalothin therapy." Br Med J 2 (1973): 396-7
Yasuhara H, Kobayashi S, Sakamoto K, Kamijo K "Pharmacokinetics of amikacin and cephalothin in bedridden elderly patients." J Clin Pharmacol 22 (1982): 403-9
Kleinknecht D, Ganeval D, Droz D "Acute renal failure after high doses of gentamicin and cephalothin." Lancet 05/19/73 (1973): 1129
Sanders WE, Jr Johnson JE, 3d Taggart JG "Adverse reactions to cephalothin and cephapirin. Uniform occurrence on prolonged intravenous administration of high doses." N Engl J Med 290 (1974): 424-9
Tvedegaard E "Letter: Interaction between gentamicin and cephalothin as cause of acute renal failure." Lancet 2 (1976): 581
Kabins SA, Cohen S "Cephalothin serum levels in the azotemic patient." Antimicrob Agents Chemother 10 (1964): 207-14
Pickering MJ, Spooner GR, Quesada A, de Cade JR "Declining renal function associated with administration of cephalothin." South Med J 63 (1970): 426-8
Gonzalez-Vitale JC, hayes DM, Cvitkovic E, Sternberg SS "Acute renal failure after cis-Dichlorodiammineplatinum (II) and gentamicin-cephalothin therapies." Cancer Treat Rep 62 (1978): 693-8
Aronoff GR, Brier RA, Sloan RS, Brier ME "Interactions of ceftazidime and tobramycin in patients with normal and impaired renal function." Antimicrob Agents Chemother 34 (1990): 1139-42
Schentag JJ, Cerra FB, Plaut ME "Clinical and pharmacokinetic characteristics of aminoglycoside nephrotoxicity in 201 critically ill patients." Antimicrob Agents Chemother 21 (1982): 721-6
Foord RD "Cephaloridine, cephalothin and the kidney." J Antimicrob Chemother 1 (1975): 119-33
Aronoff GR, Brier RA, Sloan RS, Brier ME "Interactions of ceftazidime and tobramycin in patients with normal and impaired renal function." Antimicrob Agents Chemother 34 (1990): 1139-42
Plager JE "Association of renal injury with combined cephalothin-gentamicin therapy among patients severely ill with malignant disease." Cancer 37 (1976): 1937-43
Schultze RG, Winters RE, Kauffman H "Possible nephrotoxicity of gentamicin." J Infect Dis 124 (1971): s145-7
Dellinger P, Murphy T, Barza M, et al "Effect of cephalothin on renal cortical concentrations of gentamicin in rats." Antimicrob Agents Chemother 9 (1976): 587-8
Cerner Multum, Inc. "Australian Product Information." O 0
Wade J, Smith C, Petty B, et al "Nephrotoxicity of gentamicin or tobramycin with methicillin or cephalothin." Curr Chem 2 (1978): 971-2
Klastersky J, Hensgens C, Debusscher L "Empiric therapy for cancer patients: comparative study of ticarcillin-tobramycin, ticarcillin-cephalothin, and cephalothin-tobramycin." Antimicrob Agents Chemother 7 (1975): 640-5
Hansen MM, Kaaber K "Nephrotoxicity in combined cephalothin and gentamicin therapy." Acta Med Scand 201 (1977): 463-7
Cockram CS, Richards P, Bax RP "The safety of cefuroxime and gentamicin in patients with reduced renal function." Curr Med Res Opin 6 (1980): 398-403
"Renal failure in combined gentamicin and cephalothin therapy." Br Med J 2 (1973): 776-7
Gurwich EL, Sula J, Hoy RH "Gentamicin-cephalothin drug reaction." Am J Hosp Pharm 35 (1978): 1402-3
"Product Information. Mycifradin (neomycin)." Emerson Laboratories, Texarkana, TX.
Fanning WL, Gump D, Jick H "Gentamicin- and cephalothin-associated rises in blood urea nitrogen." Antimicrob Agents Chemother 10 (1976): 80-2
Trollfors B, Alestig K, Rodjer S, Sandberg T, Westin J "Renal function in patients treated with tobramycin-cefuroxime or tobramycin-penicillin G." J Antimicrob Chemother 12 (1983): 641-5
Krcmery V, Fuchsberger P, Gocar M, et al "Nephrotoxicity of aminoglycosides, polypeptides and cephalosporins in cancer patients." Chemotherapy 37 (1991): 287-91
Barbhaiya RH, Knupp CA, Pfeffer M, Pittman KA "Lack of pharmacokinetic interaction between cefepime and amikacin in humans." Antimicrob Agents Chemother 36 (1992): 1382-6
Wade JC, Smith CR, Petty BG, et al "Cephalothin plus an aminoglycoside is more nephrotoxic than methicillin plus an aminoglycoside." Lancet 2 (1978): 604-6
Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]):
Engle JE, Drago J, Carlin B, Schoolwerth AC "Letter: Reversible acute renal failure after cephalothin." Ann Intern Med 83 (1975): 232-3
Kleinknecht D, Ganeval D, Droz D "Acute renal failure after high doses of gentamicin and cephalothin." Lancet 1 (1973): 1129
Fanning WL, Gump D, Jick H "Gentamicin and cephalothin-associated rises in blood urea nitrogen." Antimicrob Agents Chemother 10 (1976): 80-2
Carling PC, Idelson BA, Casano AA, Alexander EA, McCabe WR "Nephrotoxicity associated with cephalothin administration." Arch Intern Med 135 (1975): 797-801
Bobrow SN, Jaffe E, Young RC "Anuria and acute tubular necrosis associated with gentamicin and cephalothin." JAMA 222 (1972): 1546-7
Cabanillas F, Burgos RC, Rodriguez C, Baldizon C "Nephrotoxicity of combined cephalothin-gentamicin regimen." Arch Intern Med 135 (1975): 850-2
Tobias JS, Whitehouse JM, Wrigley PF "Letter: Severe renal dysfunction after tobramycin/cephalothin therapy." Lancet 1 (1976): 425
Rodjer S, Alestig K, Bergmark J, et al "Treatment of septicaemia in immunocompromised patients with ceftazidime, or with tobramycin and cefuroxime, with special reference to renal effects." J Antimicrob Chemother 20 (1987): 109-16
Pasternak DP, Stephens BG "Reversible nephrotoxicity associated with cephalothin therapy." Arch Intern Med 135 (1975): 599-602
"Product Information. Arikayce (amikacin liposome)." Insmed Incorporated, Bridgewater, NJ.
Schwartz JH, Schein P "Fanconi syndrome associated with cephalothin and gentamicin therapy." Cancer 41 (1978): 769-72