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Darunavir Tablets 与 Prograf (Tacrolimus Capsules)

Darunavir Tablets 与 Prograf (Tacrolimus Capsules)互相作用以及同时服用的可能性。

检测结果:

Darunavir Tablets <> Prograf (Tacrolimus Capsules)

现实性: 01.10.2022 评论家: 医学副博士Shkutko P.M., in

在该服务的官方手册中，已注明相关研究结果统计规定的互相作用。该互相作用或对患者健康引起不良后果，或起到良好效果。具体联合用药问题，需遵从医嘱。

用户:

使用藤一起那韦可能增加的影响他克莫司。联系您的医生，如果你的经验苍白的皮肤，很容易淤血或血，不寻常的虚弱、发热、冷、身体疼痛，流感的症状，尿痛，血液在你的尿液、尿比平常少或者没有，肌肉软弱、疲倦、快速或怦怦直跳的心跳和轻度呼吸急促。如果你的医生，并规定这些药物在一起，可能需要的剂量调整或特别的测试安全地使用这两种药物。重要的是要告诉你的医生关于所有其他药物的使用，包括维生素和草药。不停止使用任何药物，没有第一个说你的医生。

医界专家:

密切监测:共同给予与蛋白酶抑制剂(Pi)可能会显着增加的血液浓度藤. 拟议的机制是PI抑制的肠和肝CYP450 3A4，同工酶负责的新陈代谢的清除他克莫司。增强藤口生物利用度由于抑制肠道P-糖蛋白(P-gp)外排运输也可以作出贡献。已经有许多报告藤相互作用的各种PI含方案，在医学文献中，这需要大(>10倍)削减或中断藤给药。

管理：谨慎建议时藤用的蛋白酶抑制剂(Pi). 剂量的减少和/或延长的配量时间间隔藤将可能是需要的。藤血液水平和肾功能应当经常检查和剂量进行相应的调整，特别是以下启动或中止的PI治疗。应密切监测患者的发展严重的不良影响，如肾中毒、淋巴瘤和其他恶性肿瘤、传染病、糖尿病、神经毒性(震颤、感觉异常,脑病，谵妄、昏迷),高血钾,脱延长，心肌肥大和高血压。患者应建议寻求迅速的医疗注意，如果他们遇到的症状可能表明发生心动de扭转性，例如头晕、头晕、昏厥，心悸，不规则的心律、呼吸急促，或者昏厥。

来源

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