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EQL Daytime Cold/Flu Relief 与 Wellbutrin XL

EQL Daytime Cold/Flu Relief 与 Wellbutrin XL互相作用以及同时服用的可能性。

检测结果:

EQL Daytime Cold/Flu Relief <> Wellbutrin XL

现实性: 15.10.2022 评论家: 医学副博士Shkutko P.M., in

在该服务的官方手册中，已注明相关研究结果统计规定的互相作用。该互相作用或对患者健康引起不良后果，或起到良好效果。具体联合用药问题，需遵从医嘱。

用户:

安非他酮可能会增加血液水平和效果的右美沙芬。你可能需要的剂量调整或更频繁的监测通过你的医生到安全地使用这两种药物。联系您的医生，如果你的经验增加的副作用或条件的变化。重要的是要告诉你的医生关于所有其他药物的使用，包括维生素和草药。不停止使用任何药物，没有第一个说你的医生。

医界专家:

调节剂量：共同给予与安非他酮可能增加等离子浓度的药物，是代谢通过CYP450 2D6(例如，选择性的血清素再吸收抑制剂；三环抗抑郁药；一些β受体阻滞剂、抗心律失常药和抗精神病药物). 该机制降低清关，由于抑制CYP450 2D6活动由安非他酮。大约93%的高加索人和超过98％的亚洲人和个人的非洲人后裔问题是广泛的代谢者的CYP450 2D6和可能受此影响的互动。在一项研究的15男性志愿人员广泛的代谢者的CYP450 2D6、行政管理的一个单一的50毫克的剂量的地昔帕明以下治疗安非他酮150毫克每天两次增加的地昔帕明的峰值等离子浓度(C)、系统暴露(AUC)和半衰期通过一个平均水平的2-5分，2倍，分别。效果是目前至少7天后的最后一剂量的安非他酮。一个案例报告描述了4倍的增长，在血浆水平丙咪嗪及其代谢物，地昔帕明，在64岁的女人的下列另外的安非他酮225毫克/天。血浆水平的地昔帕明是增加了两倍多的丙咪嗪的水平，这是一致的事实，地昔帕明是主要代谢通过CYP450 2D6同时丙咪嗪也是代谢通过其他CYP450同功. 在另一份报告，一名83岁的妇女成为不稳定的、混乱和昏昏沉沉的下列另外的安非他酮SR300毫克/天。她郁症级别被发现具有增加185%. 稍后再提示再次发生相互作用。同样，一个62岁的妇女与没有历史记录的缉获量开发一个广义的补-阵挛性扣押在关联的与毒曲米帕明等离子体水平下列另外的安非他酮300毫克/天。没有进一步的缉获量发生下列用量减少的药物。

管理：谨慎建议，如果安非他酮的使用必须同时与药物，经过新陈代谢通过CYP450 2D6，特别是那些与一个狭窄的治疗范围。伴随药物应该开始在下端的剂量范围。临床和实验室监控可以适用于某些药物只要安非他酮加入或撤离治疗。

来源

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"Grapefruit juice interactions with drugs." Med Lett Drugs Ther 37 (1995): 73-4
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"Product Information. Sular (nisoldipine)." Zeneca Pharmaceuticals, Wilmington, DE.
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Josefsson M, Zackrisson AL, Ahlner J "Effect of grapefruit juice on the pharmacokinetics of amlodipine in healthy volunteers." Eur J Clin Pharmacol 51 (1996): 189-93
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Yamreudeewong W, Henann NE, Fazio A, Lower DL, Cassidy TG "Drug-food interactions in clinical practice." J Fam Pract 40 (1995): 376-84
Takanaga H, Ohnishi A, Maatsuo H, et al. "Pharmacokinetic analysis of felodipine-grapefruit juice interaction based on an irreversible enzyme inhibition model." Br J Clin Pharmacol 49 (2000): 49-58
Bailey DG, Kreeft JH, Munoz C, Freeman DJ, Bend JR "Grapefruit juice felodipine interaction: Effect of naringin and 6',7'-dihydroxybergamottin in humans." Clin Pharmacol Ther 64 (1998): 248-56
Edgar B, Bailey D, Bergstrand R, Johnsson G, Regardh CG "Acute effects of drinking grapefruit juice on the pharmacokinetics and dynamics of felodipine--and its potential clinical relevance." Eur J Clin Pharmacol 42 (1992): 313-7
"Product Information. Procardia (nifedipine)." Pfizer US Pharmaceuticals, New York, NY.
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"Product Information. Plendil (felodipine)." Merck & Co, Inc, West Point, PA.
Bailey DG, Arnold JM, Munoz C, Spence JD "Grapefruit juice--felodipine interaction: mechanism, predictability, and effect of naringin." Clin Pharmacol Ther 53 (1993): 637-42

EQL Daytime Cold/Flu Relief

非专利名称: acetaminophen / dextromethorphan / pseudoephedrine

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同义词: 无

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