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EryPed 与 Norphyl

EryPed 与 Norphyl互相作用以及同时服用的可能性。

检测结果:
EryPed <> Norphyl
现实性: 19.10.2022 评论家: 医学副博士Shkutko P.M., in

在该服务的官方手册中,已注明相关研究结果统计规定的互相作用。该互相作用或对患者健康引起不良后果,或起到良好效果。具体联合用药问题,需遵从医嘱。

用户:

使用红霉素一起茶碱可能增加的影响茶碱。 你应该联系您的医生,如果你遇到恶心、呕吐、腹泻、头痛、烦躁、失眠症,癫痫发作,或者一个心律不齐。 你可能需要的剂量调整或特别的测试安全地使用这两种药物。 重要的是要告诉你的医生关于所有其他药物的使用,包括维生素和草药。 不停止使用任何药物,没有第一个说你的医生。

医界专家:

监视器:共同给予某些大环内酯类抗生素可以增加血清浓度的茶碱,这可能导致在的毒性。 在一个情况报告,一个儿科病人制定的缉获量协会与茶碱性毒性不久之后加入红霉素。 拟议的机制是大环内酯类抑制CYP450 3A4,同工酶部分负责的代谢清除的茶碱。 数据的药物动力学研究建议的幅度的相互作用通常是最大的用醋竹桃霉素,随后通过红霉素。 与克拉霉素似乎是温和的和不一致。 阿齐和dirithromycin一般都认为有一点,如果任何影响CYP450 3A4,大多数研究没有发现显着影响的药物动力学的茶碱。 然而,一个案例报告描述了一个不寻常的互动与阿齐在老年患者由此降低血清茶碱水平多次观察到之后,停止阿齐霉素。 变化是暂时和没有需要调整的茶碱的剂量。 茶碱已经报告,以减少等离子浓度的红霉素过增加其肾间隙。

管理:药物反应和血清茶碱水平应该监测更密切地只要一个大环内酯类抗生素添加或撤销从疗法,甲基黄嘌呤剂量调整是必要的。 对于患有茶碱水平在上端的治疗范围(15至20微克/毫升),有些临床医生提出一个初始减少的甲基黄嘌呤剂量的25%当给与红霉素和50%的有醋竹桃霉素. 患者应该建议联系他们的医生如果他们的经验的迹象和症状的茶碱性毒性,如恶心、呕吐、腹泻、头痛、烦躁、失眠或者心律不齐。

来源
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EryPed

非专利名称: erythromycin

品牌: E. E. S, EryPed, EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV

同义词:

Norphyl

非专利名称: theophylline

品牌: Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap

同义词: Theophylline

在药物相容性与互相作用的检测过程中使用下列的信息来源:Drugs.com, Rxlist.com, Webmd.com, Medscape.com。

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