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Larin 24 Fe 与 Rimactane

Larin 24 Fe 与 Rimactane互相作用以及同时服用的可能性。

检测结果:

Larin 24 Fe <> Rimactane

现实性: 09.08.2022 评论家: 医学副博士Shkutko P.M., in

在该服务的官方手册中，已注明相关研究结果统计规定的互相作用。该互相作用或对患者健康引起不良后果，或起到良好效果。具体联合用药问题，需遵从医嘱。

用户:

这种药物可以降低血液水平和效果的炔雌二醇。如果您使用的低剂量口服避孕药，你可能有风险增加的突破性出血和意外怀孕。你应该讨论使用替代或额外的方法控制生育与您的医疗保健提供者。如果你采取激素替代用于更年期，通知你的医生，如果你的药疗不再控制你的症状或者你的经验异常的流血。你可能需要的剂量调整或更频繁的监测通过你的医生到安全地使用这两种药物。重要的是要告诉你的医生关于所有其他药物的使用，包括维生素和草药。不停止使用任何药物，没有第一个说你的医生。

医界专家:

其他避孕建议：共同给予有利福平或其他利福霉素类可能降低功效的避孕激素。已经有众多的情况报告的经异常(例如，突破性出血、经闭、不规则月)和意外怀孕的发生在妇女接受了口服避孕药具的用利福平。发病率的突破性出血与此相关的组合已经报告了高达75％，超过四分之三的所有指称的抗生素-口服避孕药的相互作用据报告所涉及的利福平。相互作用的源自加速清关的激素避孕，以及减少等离子浓度的未结合(活动)的激素，由于感应的肝CYP450酶的活性和激素结合的球蛋白能力通过利福平。虽然这些药物动力学影响的主要是与相关的利福平，它们也可以观察到一个较小的程度上与其他利福霉素类. 在一项研究的28健康的绝经前妇女接受组合的口服避孕药丸，共同给予有利福平(300毫克/日为10天)减少乙炔雌二醇的峰值等离子浓度(C)和系统暴露(AUC)的42%和64%，而相同的剂量利福布丁减乙炔雌二醇C和哥伦比亚联合自卫军的20%和35%。炔诺AUC也减少了60%用利福平和20%的有利福布丁. 此外，FSH和左水平的增加以下福霉素治疗，并且发病率的发现显着高之后共同给予有利福平(36.4％)和利福布丁(21.7%)比在控制的周期(3.7%).

管理：妇女使用激素避孕药，应被告知危险的突破性出血和意外怀孕期间，伴随福霉素治疗，甚至当中给出的短期课程。替代或额外的方法控制生育期间应使用和至少两个星期之后的短期的和4个星期之后长期(大于4周)福霉素治疗。如果一个组合的口服避孕药是使用，一方案含有至少50微克的乙炔雌二醇每天或相当于应选择。虽然突破性出血不一定是指示性的低乙炔雌二醇的血清水平或增加的风险的排卵，一些临床医生建议的妇女经验的突破时出血酶诱导疗法可能规定增加剂量乙炔雌二醇上述的50微克的日常通过合并多个制剂的避孕药丸，如果有必要的。对于紧急避孕者使用的一种肝酶诱导剂在过去4周，非紧急荷尔蒙避孕药具(例如，铜宫内装置)被认为是可取的。如果这是不可能的，有些当局的建议通常剂量的左炔诺孕酮(1.5毫克)应增加一倍至3毫克，并采取作为一个单剂量尽快(在72小时内未受保护的性交). 然而，目前尚无数据可证明效力、合规性或副作用的这种方案。对于妇女与依托孕烯皮下植入物，另外一个障碍的方法是建议在伴随使用和28天之后停止的肝酶诱导的药物。它建议删除植入物，并规定一个nonhormonal方法在妇女需要长期治疗肝酶诱导的药物。没有预防措施或提出建议，供妇女使用激素释放宫内节育系统，但是显着的相互作用与这些系统被认为是不太可能由于他们的地方行动。注射孕只避孕药具也被认为是不受影响，通过利福霉素类.

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Larin 24 Fe

非专利名称: ethinyl estradiol / norethindrone

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