根据名称进行药物检索

Mapap PM 与 Mellaril

Mapap PM 与 Mellaril互相作用以及同时服用的可能性。

检测结果:

Mapap PM <> Mellaril

现实性: 16.06.2022 评论家: 医学副博士Shkutko P.M., in

在该服务的官方手册中，已注明相关研究结果统计规定的互相作用。该互相作用或对患者健康引起不良后果，或起到良好效果。具体联合用药问题，需遵从医嘱。

用户:

使用硫利达嗪与苯海拉明，不建议。结合这些药物可能增加的血液水平的硫利达嗪到危险的水平，并会导致一个不规则的心脏的节奏可能是严重的和潜在威胁生命的。你应该立即寻求医疗照顾，如果你开发的突然眩晕、头晕、眩晕、呼吸急促、或心悸治疗期间，硫利达嗪. 重要的是要告诉你的医生关于所有其他药物的使用，包括维生素和草药。不停止使用任何药物，没有第一个说你的医生。

医界专家:

禁忌:共同给予的抑制剂CYP450 2D6可能增加等离子浓度硫利达嗪及其两个活动的代谢产物，mesoridazine和sulforidazine，所有这些都是基于同工酶. 显着增加(达到几倍)已经观察到在共同给予与沙明,这种药物，并吲哚洛尔在药物动力学研究。使用硫利达嗪已经与剂量相关的延长夸脱间间隔，因而升高的血浆水平的药物可能会使可能的风险室性心律失常，如室性心动过速和心动de扭转性以及心脏病和突然死亡。若干情况下的心动de扭转性的报告。

管理：使用硫利达嗪与药物抑制CYP450 2D6被认为是禁忌。根据《消除一半生活的这些药物，相当多的等待期可以适当下他们停止前硫利达嗪是发起的。例如，制造商的氟西汀的建议，硫利达嗪不能给予内的5个星期后中止氟西汀的，因为药物的长久半衰期。

来源

Greendyke RM, Gulya A "Effect of pindolol administration on serum levels of thioridazine, haloperidol, phenytoin, and phenobarbital." J Clin Psychiatry 49 (1988): 105-7
Carrillo JA, Ramos SI, Herraiz AG, Llerena A, Agundez JAG, Berecz R, Duran M, Benitez J "Pharmacokinetic interaction of fluvoxamine and thioridazine in schizophrenic patients." J Clin Psychopharmacol 19 (1999): 494-9
Glassman AH, Bigger JT Jr "Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death." Am J Psychiatry 158 (2001): 1774-82
Abernethy DR, Greenblatt DJ, Steel K, Shader RI "Impairment of hepatic drug oxidation by propoxyphene." Ann Intern Med 97 (1982): 223-4
Fletcher GF, Kazamias TM "Cardiotoxic effects of Mellaril: conduction disturbances and supraventricular arrhythmias." Am Heart J 78 (1969): 135-8
"Product Information. Prozac (fluoxetine)." Dista Products Company, Indianapolis, IN.
Markowitz JS, Wells BG, Carson WH "Interactions between antipsychotic and antihypertensive drugs." Ann Pharmacother 29 (1995): 603-9
"Product Information. Mellaril (thioridazine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
Silver JM, Yudofsky SC, Kogan M, Katz BL "Elevation of thioridazine plasma levels by propranolol." Am J Psychiatry 143 (1986): 1290-2
Hartigan-Go K, Bateman DN, Nyberg G, Martensson E, Thomas SHL "Concentration-related pharmacodynamic effects of thioridazine and its metabolites in humans." Clin Pharmacol Ther 60 (1996): 543-53
Greendyke RM, Kanter DR "Plasma propranolol levels and their effect on plasma thioridazine and haloperidol concentrations." J Clin Psychopharmacol 7 (1987): 178-82
Thomas M, Maconochie JG, Fletcher E "The dilemma of the prolonged QT interval in early drug studies." Br J Clin Pharmacol 41 (1996): 77-81

Mapap PM

非专利名称: acetaminophen / diphenhydramine

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