Microgestin Fe 1.5/30 与 Phenobarbital Injection
Microgestin Fe 1.5/30 与 Phenobarbital Injection互相作用以及同时服用的可能性。
在该服务的官方手册中,已注明相关研究结果统计规定的互相作用。该互相作用或对患者健康引起不良后果,或起到良好效果。具体联合用药问题,需遵从医嘱。
用户:苯巴比妥可以降低血液水平和效果的炔雌二醇。 如果您使用的低剂量口服避孕药,你可能有风险增加的突破性出血和意外怀孕。 你应该讨论使用替代或额外的方法控制生育与您的医疗保健提供者。 如果你采取激素替代用于更年期,通知你的医生,如果你的药疗不再控制你的症状或者你的经验异常的流血。 你可能需要的剂量调整或更频繁的监测通过你的医生到安全地使用这两种药物。 重要的是要告诉你的医生关于所有其他药物的使用,包括维生素和草药。 不停止使用任何药物,没有第一个说你的医生。
医界专家:其他避孕建议:共同给予某些抗惊厥药如卡马西平,eslicarbazepine、奥卡西平,苯巴比妥、苯妥英、和扑米酮可能会降低效的避孕激素。 已经有众多的情况报告的经异常(例如,突破性出血、经闭、不规则月)和意外怀孕的发生在妇女接受了口服避孕药具的用抗惊厥药。 发病率的月经不规则与此相关的组合已经报道尽可能高达65%,在一些研究。 相互作用的源自加速清关的激素避孕,以及减少等离子浓度的未结合(活动)的激素,由于感应的肝CYP450酶的活性和激素结合的球蛋白能力通过一些抗惊厥药。 药物动力学研究发现,通常推荐剂量的卡马西平,奥卡西平,苯巴比妥,并苯妥英能单独地减少乙炔雌二醇和左炔诺孕酮的系统暴露(AUC)通过的第三个或更多。 Eslicarbazepine酸乙酯1200毫克每天一次,为期2周的减少意味着哥伦比亚联合自卫军的单剂量乙炔雌二醇(30微克)和左炔诺孕酮(150微克)32%和24%,同时分别eslicarbazepine800毫克每天一次下降的意思是AUCs25%和11%。
管理:妇女使用激素避孕药,应被告知危险的突破性出血和意外怀孕期间,伴随治疗与酶诱导的抗惊厥药。 替代或额外的方法控制生育期间应使用和至少两个星期之后的短期的和4个星期之后长期(大于4周)的抗惊厥疗法治疗。 如果一个组合的口服避孕药是使用,一方案含有至少50微克的乙炔雌二醇每天或相当于应当予以考虑。 虽然突破性出血不一定是指示性的低乙炔雌二醇的血清水平或增加的风险的排卵,一些临床医生建议的妇女经验的突破时出血酶诱导疗法可能规定增加剂量乙炔雌二醇上述的50微克的日常通过合并多个制剂的避孕药丸,如果有必要的。 对于紧急避孕者使用的一种肝酶诱导剂在过去4周,非紧急荷尔蒙避孕药具(例如,铜宫内装置)被认为是可取的。 如果这是不可能的,有些当局的建议通常剂量的左炔诺孕酮(1.5毫克)应增加一倍至3毫克,并采取作为一个单剂量尽快(在72小时内未受保护的性交). 然而,目前尚无数据可证明效力、合规性或副作用的这种方案。 对于妇女与依托孕烯皮下植入物,另外一个障碍的方法是建议在伴随使用和28天之后停止的肝酶诱导的药物。 它建议删除植入物,并规定一个nonhormonal方法在妇女需要长期治疗肝酶诱导的药物。 没有预防措施或提出建议,供妇女使用激素释放宫内节育系统,但是显着的相互作用与这些系统被认为是不太可能由于他们的地方行动。 注射孕只避孕药具也被认为是不受酶诱导的药物。
- Fattore C, Cipolla G, Gatti G, Limido GL, Sturm Y, Bernasconi C, Perucca E "Induction of ethinylestradiol and levonorgestrel metabolism by oxcarbazepine in healthy women." Epilepsia 40 (1999): 783-7
- Odlind V, Olsson SE "Enhanced metabolism of levonorgestrel during phenytoin treatment in a woman with norplant implants." Contraception 33 (1986): 257-61
- Back DJ, Grimmer SF, Orme ML, Proudlove D, Mann RD, Breckenridge AM "Evaluation of Committee on Safety of Medicines yellow card reports on oral contraceptive-drug interactions with anticonvulsants and antibiotics." Br J Clin Pharmacol 25 (1988): 527-32
- "Product Information. Norplant System (levonorgestrel)" Wyeth-Ayerst Laboratories, Philadelphia, PA.
- Faculty of Sexual & Reproductive Healthcare "FSRH Clinical Guidance: Drug Interactions with Hormonal Contraception. Available from: URL: file:///C:/Users/df033684/Downloads/ceuguidancedruginteractionshormonal.pdf." ([2012, Jan 1]):
- Janz D, Schmidt D "Letter: Anti-epileptic drugs and failure of oral contraceptives." Lancet 1 (1974): 1113
- Coulam CB, Annegers JF "Do anticonvulsants reduce the efficacy of oral contraceptives?" Epilepsia 20 (1979): 519-26
- Furlan AJ, Rothner AD "Anti-epileptic drugs and failure of oral contraceptives." Lancet 1 (1974): 1113
- Mattson RH, Cramer JA, Darney PD, Naftolin F "Use of oral contraceptives by women with epilepsy." JAMA 256 (1986): 238-40
- Laengner H, Detering K "Letter: Anti-epileptic drugs and failure of oral contraceptives." Lancet 2 (1974): 600
- Baciewicz AM "Oral contraceptive drug interactions." Ther Drug Monit 7 (1985): 26-35
- Back DJ, Bates M, Bowden A, et al "The interaction of phenobarbital and other anticonvulsants with oral contraceptive steroid therapy." Contraception 22 (1980): 495-503
- "FFPRHC Guidance (April 2005). Drug interactions with hormonal contraception." J Fam Plann Reprod Health Care 31 (2005): 139-51
- Klosterskov Jensen P, Saano V, Haring P, Svenstrup B, Menge GP "Possible interaction between oxcarbazepine and an oral contraceptive." Epilepsia 33 (1992): 1149-52
- Dossetor J "Drug interactions with oral contraceptives." Br Med J 4 (1975): 467-8
- "Product Information. Aptiom (eslicarbazepine)." Sunovion Pharmaceuticals Inc, Marlborough, MA.
- O'Brien MD, Guillebaud J "Contraception for women with epilepsy." Epilepsia 47 (2006): 1419-22
- D'Arcy PF "Drug interactions with oral contraceptives." Drug Intell Clin Pharm 20 (1986): 353-62
- "Product Information. Fycompa (perampanel)." Eisai Inc, Teaneck, NJ.
- Rapport DJ, Calabrese JR "Interactions between carbamazepine and birth control pills." Psychosomatics 30 (1989): 462-4
- Saano V, Glue P, Banfield CR "Effects of felbamate on the pharmacokinetics of a low-dose combination oral contraceptive." Clin Pharmacol Ther 58 (1995): 523-31
- Back DJ, Orme ML "Pharmacokinetic drug interactions with oral contraceptives." Clin Pharmacokinet 18 (1990): 472-84
- Crawford P, Chadwick DJ, Martin C, et al "The interaction of phenytoin and carbamazepine with combined oral contraceptive steroids." Br J Clin Pharmacol 30 (1990): 892-6
- Diamond MP, Greene JW, Thompson JM, VanHooydonk JE, Wentz AC "Interaction of anticonvulsants and oral contraceptives in epileptic adolescents." Contraception 31 (1985): 623-32
- Szoka PR, Edgren RA "Drug interactions with oral contraceptives: compilation and analysis of an adverse experience report database." Fertil Steril 49 (1988): s31-8
- Notelovitz M, Tjapkes J, Ware M "Interaction between estrogen and dilantin in a menopausal woman." N Engl J Med 304 (1981): 788-9
- Back DJ, Breckenridge AM, Crawford FE, MacIver M, Orne ML, Rowe PH "Interindividual variation and drug interactions with hormonal steroid contraceptives." Drugs 21 (1981): 46-61
- Schindlbeck C, Janni W, Friese K "Failure of Implanon contraception in a patient taking carbamazepin for epilepsia." Arch Gynecol Obstet 273 (2006): 255-6
- Wilbur K, Ensom MHH "Pharmacokinetic drug interactions between oral contraceptives and second-generation anticonvulsants." Clin Pharmacokinet 38 (2000): 355-65
- "Product Information. Trileptal (oxcarbazepine)" Novartis Pharmaceuticals, East Hanover, NJ.
- Kenyon IE "Unplanned pregnancy in an epileptic. (Letter to the editor)." Br Med J 1 (1972): 686
- Haukkamaa M "Contraception by Norplant subdermal capsules is not reliable in epileptic patients on anticonvulsant treatment." Contraception 33 (1986): 559-65
- Shane-McWorter L, Cerveny JD, MacFarlane LL, Osborn C "Enhanced metabolism of levonorgestrel during phenobarbital treatment and resultant pregnancy." Pharmacotherapy 18 (1998): 1360-4
非专利名称: ethinyl estradiol / norethindrone
品牌: Blisovi 24 Fe, Blisovi Fe 15/30, Blisovi Fe 1/20, Estrostep Fe, Gildess 24 Fe, Gildess Fe 15/30, Gildess Fe 1/20, Junel Fe 15/30, Junel Fe 1/20, Junel Fe 24, Larin 24 Fe, Larin Fe 15/30, Larin Fe 1/20, Lo Loestrin Fe, Loestrin 24 Fe, Loestrin Fe 15/30, Loestrin Fe 1/20, Lomedia 24 Fe, Microgestin 24 Fe, Microgestin Fe 15/30, Microgestin Fe 1/20, Tarina Fe 1/20, Taytulla, Tilia Fe, Tri-Legest Fe, Blisovi 24 Fe, Femcon Fe, Kaitlib FE, Lo Minastrin Fe, Microgestin 24 Fe, Norinyl 1+35, Ortho-Novum 7/7/7, Tri-Norinyl, Zenchent, femhrt 05 mg/25 mcg, Fyavolv, Jevantique Lo, Jinteli, Femcon Fe, Generess FE, Loestrin 1/20, Ovcon 35, Brevicon
同义词: 无
非专利名称: phenobarbital
品牌: Solfoton, Luminal
同义词: Phenobarbital, PHENobarbital
在药物相容性与互相作用的检测过程中使用下列的信息来源:Drugs.com, Rxlist.com, Webmd.com, Medscape.com。
- Microgestin Fe 1.5/30-Phenobarbital Oral Solution
- Microgestin Fe 1.5/30-Phenobarbital Sodium
- Microgestin Fe 1.5/30-Phenobarbital Sodium Injection
- Microgestin Fe 1.5/30-Phenobarbital Tablets
- Microgestin Fe 1.5/30-Phenobarbital with Belladonna Alkaloids Elixir
- Microgestin Fe 1.5/30-Phenohytro
- Phenobarbital Injection-Microgestin Fe 1/20
- Phenobarbital Injection-Micronase
- Phenobarbital Injection-Microzide
- Phenobarbital Injection-Midamor
- Phenobarbital Injection-Midazolam
- Phenobarbital Injection-Midazolam Hydrochloride